2018
Alcohol and Mortality
Eyawo O, McGinnis KA, Justice AC, Fiellin DA, Hahn JA, Williams EC, Gordon AJ, Marshall BDL, Kraemer KL, Crystal S, Gaither JR, Edelman EJ, Bryant KJ, Tate JP. Alcohol and Mortality. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2018, 77: 135-143. PMID: 29112041, PMCID: PMC5762259, DOI: 10.1097/qai.0000000000001588.Peer-Reviewed Original ResearchConceptsHepatitis C virusAlcohol exposureAlcohol useDirect biomarkerVeterans Aging Cohort Study Biomarker CohortBlood collection dateRecent alcohol exposureHIV viral suppressionUnhealthy alcohol useRelationship of alcoholAUDIT-C scoresViral suppressionC virusHigh riskRisk of harmHIVClinical settingMortalityPEthExposureBiomarkersRiskImproved detectionAuditIndividuals
2017
Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B
Justice AC, McGinnis KA, Tate JP, Xu K, Becker WC, Zhao H, Gelernter J, Kranzler HR. Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B. Alcohol Clinical And Experimental Research 2017, 41: 998-1003. PMID: 28295416, PMCID: PMC5501250, DOI: 10.1111/acer.13373.Peer-Reviewed Original ResearchConceptsHarmful alcohol useAlcohol exposureAlcohol useElectronic health record dataEHR dataAUDIT-C scoresHealth record dataLongitudinal electronic health record dataLongitudinal trajectoriesChi-square testEHR-derived phenotypesStudy cohortBlood drawCommon missense polymorphismGenetic risk variantsBlood samplingMissense polymorphismAlcohol riskQuantitative biomarkersRecord dataMedianRisk variantsOverall sampleAfrican AmericansADH1B gene
2016
Risk of mortality and physiologic injury evident with lower alcohol exposure among HIV infected compared with uninfected men
Justice AC, McGinnis KA, Tate JP, Braithwaite RS, Bryant KJ, Cook RL, Edelman EJ, Fiellin LE, Freiberg MS, Gordon AJ, Kraemer KL, Marshall BD, Williams EC, Fiellin DA. Risk of mortality and physiologic injury evident with lower alcohol exposure among HIV infected compared with uninfected men. Drug And Alcohol Dependence 2016, 161: 95-103. PMID: 26861883, PMCID: PMC4792710, DOI: 10.1016/j.drugalcdep.2016.01.017.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyRisk of mortalityAUDIT-C scoresUninfected individualsPhysiologic injuryAlcohol exposureUndetectable HIV-1 RNACox proportional hazards modelAlcohol useVACS Index scoreHepatitis C infectionAging Cohort StudyHIV-1 RNAProportional hazards modelAlcohol consumption limitsLow alcohol exposureAlcohol-related harmRace/ethnicityAntiretroviral therapyC infectionUninfected menCohort studyHIV statusHazards modelIndex score
2006
Medical Disease and Alcohol Use Among Veterans With Human Immunodeficiency Infection
Justice AC, Lasky E, McGinnis KA, Skanderson M, Conigliaro J, Fultz SL, Crothers K, Rabeneck L, Rodriguez-Barradas M, Weissman SB, Bryant K. Medical Disease and Alcohol Use Among Veterans With Human Immunodeficiency Infection. Medical Care 2006, 44: s52-s60. PMID: 16849969, DOI: 10.1097/01.mlr.0000228003.08925.8c.Peer-Reviewed Original ResearchConceptsICD-9 diagnostic codesICD-9 codesChart reviewMedical diseasesDiagnostic codesAlcohol useHepatitis CLevel of exposureHIV infectionAlcohol exposureMultivariate modelGreater exposure levelsCD4 cell countHIV-positive patientsIntravenous drug useObstructive lung diseaseHuman immunodeficiency infectionCurrent alcohol useNonlinearity of associationsDiagnosis of abuseCohort studyBacterial pneumoniaPast drinkersViral loadLung disease