2014
Adiponectin Gene Polymorphisms and Acute Respiratory Distress Syndrome Susceptibility and Mortality
Ahasic AM, Zhao Y, Su L, Sheu CC, Thompson BT, Christiani DC. Adiponectin Gene Polymorphisms and Acute Respiratory Distress Syndrome Susceptibility and Mortality. PLOS ONE 2014, 9: e89170. PMID: 24586568, PMCID: PMC3929660, DOI: 10.1371/journal.pone.0089170.Peer-Reviewed Original ResearchConceptsARDS casesInsulin resistanceSingle nucleotide polymorphismsCase statusAcute respiratory distress syndrome (ARDS) riskFunctional polymorphismsAnti-inflammatory adipokineAcute respiratory failureDevelopment of ARDSAdiponectin gene polymorphismsMultiple comparisonsAdipokine levelsCause mortalityRespiratory failureAdiponectin levelsCritical illnessConsecutive patientsMultivariable analysisRisk factorsSyndrome riskCardiovascular diseaseAdipose tissueGene polymorphismsARDSMortality
2012
Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin
Tejera P, Meyer NJ, Chen F, Feng R, Zhao Y, O'Mahony DS, Li L, Sheu CC, Zhai R, Wang Z, Su L, Bajwa E, Ahasic AM, Clardy PF, Gong MN, Frank AJ, Lanken PN, Thompson BT, Christie JD, Wurfel MM, O'Keefe GE, Christiani DC. Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin. Journal Of Medical Genetics 2012, 49: 671. PMID: 23048207, PMCID: PMC3654537, DOI: 10.1136/jmedgenet-2012-100972.Peer-Reviewed Original ResearchConceptsAcute lung injuryALI/ARDSIndirect lung injuryRisk of ARDSRespiratory distress syndromeLung injuryExtrapulmonary causesDistress syndromeIndirect insultsSingle nucleotide polymorphismsStage IIAcute respiratory distress syndromeDevelopment of ARDSGenetic variantsGenetic risk factorsIll Caucasian patientsFunctional single nucleotide polymorphismsALI/Extrapulmonary injuryPulmonary sepsisPulmonary injuryExtrapulmonary originCaucasian patientsRisk factorsARDS
2011
IGF1 and IGFBP3 in acute respiratory distress syndrome
Ahasic AM, Zhai R, Su L, Zhao Y, Aronis KN, Thompson BT, Mantzoros CS, Christiani DC. IGF1 and IGFBP3 in acute respiratory distress syndrome. European Journal Of Endocrinology 2011, 166: 121-129. PMID: 22004906, PMCID: PMC3757506, DOI: 10.1530/eje-11-0778.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeLevels of IGF1Development of ARDSRespiratory distress syndromeIGFBP3 levelsARDS casesDistress syndromePersistent acute respiratory distress syndromeFibrotic lung diseaseSeverity of illnessIntensive care unitCase-cohort studyRelevant clinical covariatesCause mortalityConsecutive patientsCare unitLung diseaseRisk factorsClinical covariatesPlasma IGF1Parent studyCase statusPatientsIGF pathwayDay 60