2019
The Clinical Utility of a Precision Medicine Blood Test Incorporating Age, Sex, and Gene Expression for Evaluating Women with Stable Symptoms Suggestive of Obstructive Coronary Artery Disease: Analysis from the PRESET Registry
Gul B, Lansky A, Budoff MJ, Sharp D, Maniet B, Herman L, Kuo JZ, Huang L, Monane M, Ladapo JA. The Clinical Utility of a Precision Medicine Blood Test Incorporating Age, Sex, and Gene Expression for Evaluating Women with Stable Symptoms Suggestive of Obstructive Coronary Artery Disease: Analysis from the PRESET Registry. Journal Of Women's Health 2019, 28: 728-735. PMID: 30653377, PMCID: PMC6537117, DOI: 10.1089/jwh.2018.7203.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary artery diseaseFurther cardiac evaluationCardiac evaluationArtery diseaseClinical utilityStable obstructive coronary artery diseaseMajor adverse cardiac eventsMedian age 57 yearsMedian body mass indexAdverse cardiac eventsAge 57 yearsManagement of womenBody mass indexCommunity-based registryPrimary care practicesPrecision medicine testsGene expression scoreCardiac referralHypertension presentSymptoms SuggestiveCardiac eventsClinical characteristicsMass indexStudy cohort
2014
Ischemic Outcomes After Coronary Intervention of Calcified Vessels in Acute Coronary Syndromes Pooled Analysis From the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) and ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) Trials
Généreux P, Madhavan MV, Mintz GS, Maehara A, Palmerini T, LaSalle L, Xu K, McAndrew T, Kirtane A, Lansky AJ, Brener SJ, Mehran R, Stone GW. Ischemic Outcomes After Coronary Intervention of Calcified Vessels in Acute Coronary Syndromes Pooled Analysis From the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) and ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) Trials. Journal Of The American College Of Cardiology 2014, 63: 1845-1854. PMID: 24561145, DOI: 10.1016/j.jacc.2014.01.034.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionSevere target lesion calcificationAcute coronary syndromePercutaneous coronary interventionTarget lesion calcificationTarget lesion revascularizationElevation acute coronary syndromeDefinite stent thrombosisLesion calcificationStent thrombosisHORIZONS-AMICoronary syndromeCoronary interventionCoronary calcificationST-segment elevation acute coronary syndromeSegment elevation acute coronary syndromesIndependent angiographic core laboratoryStable coronary artery diseaseSevere lesion calcificationOne-year outcomesElevation myocardial infarctionCoronary artery diseaseAngiographic core laboratoryACUITY trialIschemic outcomes
2012
A gender-specific blood-based gene expression score for assessing obstructive coronary artery disease in nondiabetic patients: Results of the Personalized Risk Evaluation and Diagnosis in the Coronary Tree (PREDICT) Trial
Lansky A, Elashoff MR, Ng V, McPherson J, Lazar D, Kraus WE, Voros S, Schwartz RS, Topol EJ. A gender-specific blood-based gene expression score for assessing obstructive coronary artery disease in nondiabetic patients: Results of the Personalized Risk Evaluation and Diagnosis in the Coronary Tree (PREDICT) Trial. American Heart Journal 2012, 164: 320-326. PMID: 22980297, DOI: 10.1016/j.ahj.2012.05.012.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary artery diseaseMyocardial perfusion imagingGene expression scoreQuantitative coronary angiographyExpression scoreNondiabetic patientsArtery diseaseCardiac catheterizationCoronary angiographyBurden of CADSeverity of CADNoninvasive myocardial perfusion imagingProspective multicenter observational studyUnknown coronary artery diseaseSignificant coronary artery diseaseDiagnostic approachUnnecessary cardiac catheterizationMulticenter observational studyChest pain symptomsDiagnostic cardiac catheterizationAvailable noninvasive testsNoninvasive test resultsPositive predictive valueReliable diagnostic approach
2011
Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients
Elashoff MR, Wingrove JA, Beineke P, Daniels SE, Tingley WG, Rosenberg S, Voros S, Kraus WE, Ginsburg GS, Schwartz RS, Ellis SG, Tahirkheli N, Waksman R, McPherson J, Lansky AJ, Topol EJ. Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients. BMC Medical Genomics 2011, 4: 26. PMID: 21443790, PMCID: PMC3072303, DOI: 10.1186/1755-8794-4-26.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary artery diseaseNon-diabetic patientsDiabetic statusArtery diseaseRT-PCR analysisNon-invasive blood testStudy of patientsPeripheral blood cellsClassifier genesCell type-specific markersPREDICT cohortGene expressionClinical factorsInvasive angiographyBlood testsControl cohortRegistry casesCohort analysisPREDICT studyResultsMicroarray analysisDiagnostic utilityPopulation predictorsRT-PCR dataCAD association
2007
An evaluation of fluoroscopy time and correlation with outcomes after percutaneous coronary intervention.
Nikolsky E, Pucelikova T, Mehran R, Balter S, Kaufman L, Fahy M, Lansky AJ, Leon MB, Moses JW, Stone GW, Dangas G. An evaluation of fluoroscopy time and correlation with outcomes after percutaneous coronary intervention. Journal Of Invasive Cardiology 2007, 19: 208-13. PMID: 17476034.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAngioplasty, Balloon, CoronaryCohort StudiesCoronary AngiographyCoronary Artery BypassCoronary DiseaseElectrocardiographyFemaleFluoroscopyFollow-Up StudiesHospital MortalityHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsProbabilityRetrospective StudiesRisk FactorsSensitivity and SpecificitySeverity of Illness IndexSurvival RateTime FactorsTreatment OutcomeConceptsCoronary artery bypass surgeryPercutaneous coronary interventionEmergent coronary artery bypass surgeryPrior coronary artery bypass surgeryProlonged fluoroscopy timeContrast-induced nephropathyPeripheral arterial diseaseFluoroscopy timeBaseline TIMICoronary interventionArterial diseaseComplexity of PCIType B2/C lesionsB2/C lesionsSevere lesion calcificationChronic renal insufficiencyArtery bypass surgeryShort-term prognosisMean fluoroscopy timeHospital deathHospital outcomesPeriprocedural complicationsRenal insufficiencyBypass surgeryLesion calcification
2004
Outcome in Elderly Patients Undergoing Primary Coronary Intervention for Acute Myocardial Infarction
Guagliumi G, Stone GW, Cox DA, Stuckey T, Tcheng JE, Turco M, Musumeci G, Griffin JJ, Lansky AJ, Mehran R, Grines CL, Garcia E. Outcome in Elderly Patients Undergoing Primary Coronary Intervention for Acute Myocardial Infarction. Circulation 2004, 110: 1598-1604. PMID: 15353506, DOI: 10.1161/01.cir.0000142862.98817.1f.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAdrenergic beta-AntagonistsAdultAge FactorsAgedAged, 80 and overAngioplasty, Balloon, CoronaryAntibodies, MonoclonalAspirinCohort StudiesCombined Modality TherapyCoronary AngiographyCoronary RestenosisFemaleHemorrhageHumansImmunoglobulin Fab FragmentsLife TablesMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsProportional Hazards ModelsPyridinesStentsStrokeTreatment OutcomeConceptsAcute myocardial infarctionGlycoprotein IIb/IIIa inhibitorsPrimary percutaneous coronary interventionIIb/IIIa inhibitorsElderly patientsPercutaneous coronary interventionMajor bleedingYears of ageCoronary interventionClinical outcomesStent implantationMyocardial infarctionPlatelet glycoprotein IIb/IIIa inhibitorsDecile of ageMechanical reperfusion strategiesOne-year mortalityPrimary coronary interventionRate of strokeCoronary stent implantationImpact of ageRate of mortalityAbciximab administrationCADILLAC trialReperfusion modalityTarget revascularizationImpact of chronic kidney disease on prognosis of patients with diabetes mellitus treated with percutaneous coronary intervention
Nikolsky E, Mehran R, Turcot D, Aymong ED, Mintz GS, Lasic Z, Lansky AJ, Tsounias E, Moses JW, Stone GW, Leon MB, Dangas GD. Impact of chronic kidney disease on prognosis of patients with diabetes mellitus treated with percutaneous coronary intervention. The American Journal Of Cardiology 2004, 94: 300-305. PMID: 15276092, DOI: 10.1016/j.amjcard.2004.04.023.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAngioplasty, Balloon, CoronaryCause of DeathChi-Square DistributionCohort StudiesCoronary DiseaseDiabetic AngiopathiesFemaleHumansKidney Failure, ChronicMaleMiddle AgedProbabilityPrognosisRenal DialysisRisk AssessmentSeverity of Illness IndexSex FactorsStatistics, NonparametricStentsSurvival AnalysisTreatment OutcomeConceptsChronic kidney diseasePercutaneous coronary interventionContrast-induced nephropathyPrognosis of patientsCoronary interventionRenal functionDiabetes mellitusKidney diseaseMortality rateImpact of CKDRole of CKDDe novo dialysisOutcomes of patientsHospital complicationsGastrointestinal bleedingNeurologic eventsFrequent complicationDiabetic patientsIndependent predictorsInsulin treatmentPatientsContrast mediumNephropathyDialysisMellitus
2002
Long-Term Outcome of Patients Treated With Repeat Percutaneous Coronary Intervention After Failure of γ-Brachytherapy for the Treatment of In-Stent Restenosis
Prpic R, Teirstein PS, Reilly JP, Moses JW, Tripuraneni P, Lansky AJ, Giorgianni JA, Jani S, Wong SC, Fish RD, Ellis S, Holmes DR, Kereiakas D, Kuntz RE, Leon MB. Long-Term Outcome of Patients Treated With Repeat Percutaneous Coronary Intervention After Failure of γ-Brachytherapy for the Treatment of In-Stent Restenosis. Circulation 2002, 106: 2340-2345. PMID: 12403664, DOI: 10.1161/01.cir.0000036366.62288.74.Peer-Reviewed Original ResearchConceptsTarget lesion revascularizationIndex treatmentIntracoronary brachytherapyPercutaneous interventionStent restenosisAcceptable long-term resultsMajor adverse event rateRepeat percutaneous coronary interventionRepeat target vessel revascularizationSubsequent target lesion revascularizationTarget vessel revascularizationAcute procedural successAdverse event ratesPercutaneous coronary interventionIntracoronary radiation therapyLong-term outcomesLong-term resultsIn-Stent RestenosisLesion revascularizationPlacebo groupCoronary interventionFailure patientsProcedural successAngioplasty/Term outcomesDelivered Dose and Vascular Response After β-Radiation for In-Stent Restenosis
Morino Y, Kaneda H, Fox T, Takagi A, Hassan AH, Bonan R, Crocker I, Lansky AJ, Laskey WK, Suntharalingam M, Bonneau HN, Yock PG, Honda Y, Fitzgerald PJ. Delivered Dose and Vascular Response After β-Radiation for In-Stent Restenosis. Circulation 2002, 106: 2334-2339. PMID: 12403663, DOI: 10.1161/01.cir.0000036367.17043.03.Peer-Reviewed Original ResearchMeSH KeywordsBeta ParticlesBlood Vessel Prosthesis ImplantationBrachytherapyCohort StudiesCoronary AngiographyCoronary Artery DiseaseCoronary RestenosisCoronary VesselsDose-Response Relationship, RadiationFemaleHumansLinear ModelsMaleMiddle AgedRadiation DosageRadiometryRetrospective StudiesStentsTreatment OutcomeUltrasonography, InterventionalVascular PatencyConceptsIntimal hyperplasia volumeDose intensityVolumetric intravascular ultrasound analysisDose-dependent complicationsRadiation therapy trialsSerial Volumetric Intravascular Ultrasound AnalysisStent restenosis casesStent restenosis lesionsIn-Stent RestenosisIntravascular ultrasound analysisPrescribed radiation doseSource trainRestenosis casesRestenosis lesionsVascular changesVascular responsesTherapy trialsDose prescriptionLong subsegmentsDevice injuryUltrasound analysisStent segmentDoseDose rangeIVUS catheterLate Vascular Response to Repeat Stenting for In-Stent Restenosis With and Without Radiation
Morino Y, Limpijankit T, Honda Y, Lansky AJ, Waksman R, Bonneau HN, Yock PG, Mintz GS, Fitzgerald PJ. Late Vascular Response to Repeat Stenting for In-Stent Restenosis With and Without Radiation. Circulation 2002, 105: 2465-2468. PMID: 12034650, DOI: 10.1161/01.cir.0000018949.39445.40.Peer-Reviewed Original ResearchMeSH KeywordsBlood Vessel Prosthesis ImplantationBrachytherapyCohort StudiesCoronary RestenosisDisease ProgressionDouble-Blind MethodFollow-Up StudiesGamma RaysHumansIridium RadioisotopesPlatelet Aggregation InhibitorsRandomized Controlled Trials as TopicRecurrenceReoperationStentsTiclopidineTimeTreatment OutcomeUltrasonography, InterventionalVascular PatencyConceptsLumen volume indexISR lesionsPlacebo patientsLate vascular responseAcute angiographic resultsIntravascular ultrasound analysisIn-Stent RestenosisPlacebo groupAngiographic resultsVascular responsesAdditional lumenNeointimal proliferationStent restenosisIrradiated groupPatientsStent overlapLesionsVolume indexUltrasound analysisSafety of radiationLong-term advantagesStent strutsSignificant decreaseStentingRestenosisComparison of clinical outcomes using stents versus no stents after percutaneous coronary intervention for proximal left anterior descending versus proximal right and left circumflex coronary arteries
Ashby DT, Dangas G, Mehran R, Lansky AJ, Narasimaiah R, Iakovou I, Polena S, Satler LF, Pichard AD, Kent KM, Stone GW, Leon MB. Comparison of clinical outcomes using stents versus no stents after percutaneous coronary intervention for proximal left anterior descending versus proximal right and left circumflex coronary arteries. The American Journal Of Cardiology 2002, 89: 1162-1166. PMID: 12008168, DOI: 10.1016/s0002-9149(02)02297-x.Peer-Reviewed Original ResearchMeSH KeywordsAgedArteriesBlood Vessel Prosthesis ImplantationCohort StudiesCoronary Artery DiseaseCoronary RestenosisCoronary VesselsDistrict of ColumbiaFemaleFollow-Up StudiesHumansMaleMiddle AgedPostoperative ComplicationsRadiographyStentsStroke VolumeSurvival AnalysisTime FactorsTreatment OutcomeConceptsPercutaneous coronary interventionTarget lesion revascularizationProximal LAD arteryProximal rightClinical restenosisCoronary interventionCircumflex arteryProcedural successLAD arteryProximal coronary artery stenosisSingle-vessel coronary diseaseAnterior descending (LAD) stenosisHigh rateCircumflex coronary arteryLower procedural successCoronary artery stenosisSignificant differencesDifferent lesion locationsCoronary artery stentsLesion revascularizationProximal LADCoronary diseaseArtery stenosisClinical outcomesHospital eventsFive-year clinical and angiographic follow-up after intracoronary iridium-192 radiation therapy
Condado JA, Waksman R, Saucedo JF, Bhargava B, Lansky AJ, Calderas C, Gurdiel O, Gonzalez J, Fadoul M, Parra B, Iturria I, Amezaga B. Five-year clinical and angiographic follow-up after intracoronary iridium-192 radiation therapy. Cardiovascular Revascularization Medicine 2002, 3: 74-81. PMID: 12699836, DOI: 10.1016/s1522-1865(03)00077-5.Peer-Reviewed Original ResearchConceptsQuantitative coronary analysisIntracoronary gamma radiationBalloon angioplastyRadiation therapyAngiographic complicationsStandard balloon angioplastyBinary restenosis rateIntracoronary radiation therapyIncidence of restenosisNew adverse effectsPrevention of restenosisLesion revascularizationUnstable anginaAngioplasty siteRestenosis rateNontarget vesselsTotal occlusionMyocardial infarctionAngiographic effectsClinical trialsAneurysm formationLate lossNeointimal formationLong-term effectsPatientsImpact of normalized myocardial perfusion after successful angioplasty in acute myocardial infarction
Stone GW, Peterson MA, Lansky AJ, Dangas G, Mehran R, Leon MB. Impact of normalized myocardial perfusion after successful angioplasty in acute myocardial infarction. Journal Of The American College Of Cardiology 2002, 39: 591-597. PMID: 11849856, DOI: 10.1016/s0735-1097(01)01779-x.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionTIMI 3 flowAcute myocardial infarctionMyocardial infarctionMyocardial perfusionMyocardial blushSuccessful angioplastyAngiographic myocardial blush gradeOne-year cumulative mortalityEpicardial coronary flowMyocardial blush scoreNormal myocardial blushHigh-risk featuresHigh-risk patientsMyocardial blush gradeAbnormal myocardial perfusionMyocardial perfusion gradePercutaneous coronary interventionSurvival of patientsNormal myocardial perfusionTIMI 0Blush gradeCardiogenic shockInfarct arteryCoronary intervention
2001
Intravascular Ultrasound—Guided Renal Artery Stenting
Dangas G, Laird J, Mehran R, Lansky A, Mintz G, Leon M. Intravascular Ultrasound—Guided Renal Artery Stenting. Journal Of Endovascular Therapy 2001, 8: 238-247. PMID: 11491257, DOI: 10.1177/152660280100800302.Peer-Reviewed Original ResearchConceptsRenal arteryDiastolic arterial blood pressureLesion lengthHospital renal failureMean contrast volumePalmaz stent implantationRenal artery revascularizationRenal artery stentingStenotic renal arteriesArterial blood pressureIntravascular ultrasound guidanceMinimal luminal diameterProximal renal arteriesMajority of lesionsMean lesion lengthAntihypertensive medicationsArtery revascularizationTransient hemodialysisUncontrolled hypertensionAngiographic successRenal insufficiencyRenal failureSerum creatinineArtery stentingBlood pressure
2000
Mechanism of Lumen Enlargement During Intracoronary Stent Implantation
Ahmed J, Mintz G, Weissman N, Lansky A, Pichard A, Satler L, Kent K. Mechanism of Lumen Enlargement During Intracoronary Stent Implantation. Circulation 2000, 102: 7-10. PMID: 10880407, DOI: 10.1161/01.cir.102.1.7.Peer-Reviewed Original ResearchConceptsLumen enlargementReference segmentsExternal elastic membrane areaDistal reference segmentsNative coronary lesionsIntracoronary stent implantationIntravascular ultrasound analysisMean lumen areaExternal elastic membraneCoronary lesionsPlaque burdenPlaque embolizationStent implantationMultilink stentsProximal referenceDistal referenceIntravascular ultrasoundLesionsUltrasound analysisLumen areaPlaquesVolumetric analysisVessel expansionInterventionMedia area