A gender-specific blood-based gene expression score for assessing obstructive coronary artery disease in nondiabetic patients: Results of the Personalized Risk Evaluation and Diagnosis in the Coronary Tree (PREDICT) Trial
Lansky A, Elashoff MR, Ng V, McPherson J, Lazar D, Kraus WE, Voros S, Schwartz RS, Topol EJ. A gender-specific blood-based gene expression score for assessing obstructive coronary artery disease in nondiabetic patients: Results of the Personalized Risk Evaluation and Diagnosis in the Coronary Tree (PREDICT) Trial. American Heart Journal 2012, 164: 320-326. PMID: 22980297, DOI: 10.1016/j.ahj.2012.05.012.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary artery diseaseMyocardial perfusion imagingGene expression scoreQuantitative coronary angiographyExpression scoreNondiabetic patientsArtery diseaseCardiac catheterizationCoronary angiographyBurden of CADSeverity of CADNoninvasive myocardial perfusion imagingProspective multicenter observational studyUnknown coronary artery diseaseSignificant coronary artery diseaseDiagnostic approachUnnecessary cardiac catheterizationMulticenter observational studyChest pain symptomsDiagnostic cardiac catheterizationAvailable noninvasive testsNoninvasive test resultsPositive predictive valueReliable diagnostic approachUsefulness of Noninvasive Fractional Flow Reserve Computed from Coronary Computed Tomographic Angiograms for Intermediate Stenoses Confirmed by Quantitative Coronary Angiography
Min JK, Koo BK, Erglis A, Doh JH, Daniels DV, Jegere S, Kim HS, Dunning AM, DeFrance T, Lansky A, Leipsic J. Usefulness of Noninvasive Fractional Flow Reserve Computed from Coronary Computed Tomographic Angiograms for Intermediate Stenoses Confirmed by Quantitative Coronary Angiography. The American Journal Of Cardiology 2012, 110: 971-976. PMID: 22749390, DOI: 10.1016/j.amjcard.2012.05.033.Peer-Reviewed Original ResearchConceptsLesion-specific ischemiaFractional flow reserveCoronary lesionsIntermediate stenosisFlow reservePredictive valueNoninvasive methodComputed Tomographic AngiogramsCoronary computed tomographyNoninvasive fractional flow reserveQuantitative coronary angiographyReceiver operator characteristic curveIntermediate stenosis severityNegative predictive valuePositive predictive valueOperator characteristic curveCoronary angiographyInvasive angiographyMean ageTomographic angiogramBland-Altman analysisStudy groupIschemiaComputed tomographyNovel noninvasive method