2011
Incidence and clinical consequences of acquired thrombocytopenia after antithrombotic therapies in patients with acute coronary syndromes: Results from the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial
Caixeta A, Dangas GD, Mehran R, Feit F, Nikolsky E, Lansky AJ, Aoki J, Moses JW, Steinhubl SR, White HD, Ohman EM, Manoukian SV, Fahy M, Stone GW. Incidence and clinical consequences of acquired thrombocytopenia after antithrombotic therapies in patients with acute coronary syndromes: Results from the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial. American Heart Journal 2011, 161: 298-306.e1. PMID: 21315212, DOI: 10.1016/j.ahj.2010.10.035.Peer-Reviewed Original ResearchConceptsIIb/IIIa inhibitorsGP IIb/IIIa inhibitorsAcute coronary syndromeBivalirudin monotherapyMajor bleedingCoronary syndromePlatelet countClinical consequencesUrgent Intervention Triage Strategy (ACUITY) trialGlycoprotein IIb/IIIa inhibitorsPredictors of mortalityAcquired thrombocytopeniaACUITY trialAcute CatheterizationAntiplatelet medicationsAntithrombotic therapyIschemic complicationsAnticoagulant regimenIndependent predictorsStrategy trialThrombocytopeniaPatientsMultivariate analysisMonotherapyLess decline
2007
Impact of Baseline Platelet Count in Patients Undergoing Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction (from the CADILLAC Trial)
Nikolsky E, Grines CL, Cox DA, Garcia E, Tcheng JE, Sadeghi M, Mehran R, Lansky AJ, Na Y, Stone GW. Impact of Baseline Platelet Count in Patients Undergoing Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction (from the CADILLAC Trial). The American Journal Of Cardiology 2007, 99: 1055-1061. PMID: 17437727, DOI: 10.1016/j.amjcard.2006.11.066.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAgedAngioplasty, Balloon, CoronaryAntibodies, MonoclonalCause of DeathCoronary AngiographyCoronary RestenosisCoronary ThrombosisCreatine KinaseFemaleFollow-Up StudiesForecastingHumansImmunoglobulin Fab FragmentsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPlatelet CountPlatelet Glycoprotein GPIIb-IIIa ComplexProspective StudiesRecurrenceStentsTreatment OutcomeConceptsPrimary percutaneous coronary interventionBaseline platelet countAcute myocardial infarctionPrimary PCIHigher baseline platelet countPercutaneous coronary interventionPlatelet countCoronary interventionMyocardial infarctionAngiographic success rateTarget vessel thrombosisPowerful independent predictorMedian platelet countRole of plateletsCADILLAC trialCardiac mortalityAngiographic outcomesIndependent predictorsAngiographic resultsHighest quartileMultivariable analysisVessel thrombosisVascular responsesReinfarctionPatients
2005
Impact of In-Hospital Acquired Thrombocytopenia in Patients Undergoing Primary Angioplasty for Acute Myocardial Infarction
Nikolsky E, Sadeghi HM, Effron MB, Mehran R, Lansky AJ, Na Y, Cox DA, Garcia E, Tcheng JE, Griffin JJ, Stuckey TD, Turco M, Carroll JD, Grines CL, Stone GW. Impact of In-Hospital Acquired Thrombocytopenia in Patients Undergoing Primary Angioplasty for Acute Myocardial Infarction. The American Journal Of Cardiology 2005, 96: 474-481. PMID: 16098296, DOI: 10.1016/j.amjcard.2005.04.005.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAge DistributionAgedAngioplasty, Balloon, CoronaryAntibodies, MonoclonalCause of DeathFemaleFollow-Up StudiesHemorrhageHumansImmunoglobulin Fab FragmentsIncidenceInpatientsMaleMiddle AgedMyocardial InfarctionOdds RatioPlatelet Aggregation InhibitorsPlatelet CountProspective StudiesRisk FactorsSex DistributionSurvival RateThrombocytopeniaTreatment OutcomeConceptsPrimary percutaneous coronary interventionPercutaneous coronary interventionAcute myocardial infarctionHemorrhagic complicationsAcquired thrombocytopeniaPlatelet countMyocardial infarctionHigher baseline platelet countGreater body mass indexNadir platelet countPrevious aspirin useUse of abciximabBaseline platelet countBlood product transfusionLonger hospital stayMajor hemorrhagic complicationsHours of onsetBody mass indexAspirin useBaseline thrombocytopeniaCADILLAC trialIschemic complicationsCause mortalityHospital stayPrimary angioplasty