A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice
Nussenzweig M, Schmidt E, Shaw A, Sinn E, Campos-Torres J, Mathey-Prevot B, Pattengale P, Leder P. A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice. Nature 1988, 336: 446-450. PMID: 3143076, DOI: 10.1038/336446a0.Peer-Reviewed Original ResearchMeSH KeywordsAbelson murine leukemia virusAnimalsB-LymphocytesBone MarrowCell Transformation, NeoplasticCell Transformation, ViralEnhancer Elements, GeneticGenes, ImmunoglobulinHematopoietic Stem CellsHumansImmunoglobulin mu-ChainsLymphomaMiceMice, TransgenicPhenotypeProto-Oncogene ProteinsProto-Oncogene Proteins c-mycProto-OncogenesRNA, MessengerAllelic exclusion in transgenic mice carrying mutant human IgM genes.
Nussenzweig MC, Shaw AC, Sinn E, Campos-Torres J, Leder P. Allelic exclusion in transgenic mice carrying mutant human IgM genes. Journal Of Experimental Medicine 1988, 167: 1969-1974. PMID: 3133444, PMCID: PMC2189689, DOI: 10.1084/jem.167.6.1969.Peer-Reviewed Original ResearchConceptsAllelic exclusionHeavy chain geneChain geneMu chainsHuman mu chainsPrimary B cellsHybrid animalsIg heavy chain genesHuman heavy chainsMu expressionTransgenic mice resultsIgM geneGenesSimultaneous expressionSecreted versionTransgeneIg transgenesHeavy chainMice resultsTransgenic miceExpressionHuman Ig transgenesB cellsCellsVivo