2008
Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3β
Mohanty S, Town T, Yagi T, Scheidig C, Kwan KY, Allore HG, Flavell RA, Shaw AC. Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3β. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 5063-5068. PMID: 18367668, PMCID: PMC2278186, DOI: 10.1073/pnas.0801235105.Peer-Reviewed Original ResearchConceptsMurine embryonic fibroblastsDNA damageDependent substrate phosphorylationDNA double-strand breaksType IA topoisomerasesCell cycle checkpointsDNA-damaging agentsS cell cycle checkpointDouble-strand breaksRegulation of totalSubstrate phosphorylationGenomic stabilityDsDNA breaksDNA replicationCycle checkpointsHomologous recombinationDNA repairUnanticipated roleEmbryonic fibroblastsAtaxia telangiectasiaCellular responsesTopoisomerase 3βPhosphorylationRad3Important role
1990
Mutations of immunoglobulin transmembrane and cytoplasmic domains: Effects on intracellular signaling and antigen presentation
Shaw A, Mitchell R, Weaver Y, Campos-Torres J, Abbas A, Leder P. Mutations of immunoglobulin transmembrane and cytoplasmic domains: Effects on intracellular signaling and antigen presentation. Cell 1990, 63: 381-392. PMID: 2119890, DOI: 10.1016/0092-8674(90)90171-a.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibody FormationAntigensBase SequenceB-LymphocytesCalciumCell LineCell MembraneCytoplasmHumansImmunoglobulin mu-ChainsKineticsMiceMolecular Sequence DataMutagenesis, Site-DirectedOligonucleotide ProbesReceptors, Antigen, B-CellSequence Homology, Nucleic AcidSignal TransductionTransfectionConceptsCytoplasmic domainSignal transductionShort cytoplasmic domainDifferent protein interactionsMembrane-bound formMu chain geneProtein interactionsTransmembrane residuesIntracellular signalingChain geneSpecific mutationsTransductionAntigen presentationAntigen-specific receptorsMutationsTransmembraneB cellsGenesSignalingDomainResiduesCellsAssaysReceptors