Featured Publications
Pulmonary Capillary Wedge Pressure Patterns During Exercise Predict Exercise Capacity and Incident Heart Failure
Eisman A, Shah R, Dhakal B, Pappagianopoulos P, Wooster L, Bailey C, Cunningham T, Hardin K, Baggish A, Ho J, Malhotra R, Lewis G. Pulmonary Capillary Wedge Pressure Patterns During Exercise Predict Exercise Capacity and Incident Heart Failure. Circulation Heart Failure 2018, 11: e004750. PMID: 29695381, PMCID: PMC5937988, DOI: 10.1161/circheartfailure.117.004750.Peer-Reviewed Original ResearchConceptsHeart failure outcomesExercise capacityCardiac outcomesHeart failureLeft ventricular ejection fractionLeft ventricular filling pressureMeasure of left ventricular filling pressureComposite cardiac outcomeDefinitions of HFpEFExercise hemodynamic measurementsPeak VO<sub>2</sub>Ventricular ejection fractionAdverse cardiac outcomesVentricular filling pressureFailure outcomesCardiopulmonary exercise testingBody mass indexPredicting exercise capacityIncident heart failureDifferentiate HFpEFNon-HFpEFEjection fractionHFpEF diagnosisMm HgFollow-up
2016
Pulmonary Vascular Distensibility Predicts Pulmonary Hypertension Severity, Exercise Capacity, and Survival in Heart Failure
Malhotra R, Dhakal B, Eisman A, Pappagianopoulos P, Dress A, Weiner R, Baggish A, Semigran M, Lewis G. Pulmonary Vascular Distensibility Predicts Pulmonary Hypertension Severity, Exercise Capacity, and Survival in Heart Failure. Circulation Heart Failure 2016, 9: e003011. PMID: 27301469, PMCID: PMC4911900, DOI: 10.1161/circheartfailure.115.003011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntihypertensive AgentsArterial PressureCase-Control StudiesDouble-Blind MethodExercise TestExercise ToleranceFemaleHeart FailureHumansHypertension, PulmonaryKaplan-Meier EstimateLinear ModelsMaleMiddle AgedModels, CardiovascularMultivariate AnalysisPhosphodiesterase 5 InhibitorsPredictive Value of TestsProportional Hazards ModelsProspective StudiesPulmonary ArteryRisk AssessmentRisk FactorsSeverity of Illness IndexSildenafil CitrateStroke VolumeTime FactorsTreatment OutcomeVascular StiffnessVasodilator AgentsVentricular Function, RightConceptsPV distensibilityPulmonary arterial hypertensionReduced ejection fractionHeart failureEjection fractionExercise capacityArterial hypertensionHF patientsRight ventricular ejection fractionPulmonary artery wedge pressureReduced ejection fraction groupPulmonary arterial hypertension groupFirst-pass radionuclide ventriculographyPulmonary vasodilator therapyRV systolic functionVentricular ejection fractionLeft heart failurePulmonary artery pressureEjection fraction groupPulmonary hypertension severityRight ventricular performanceArterial hypertension groupInvasive hemodynamic monitoringWeeks of treatmentPredictors of peak VO2
2015
Native Myocardial T1 as a Biomarker of Cardiac Structure in Non-Ischemic Cardiomyopathy
Shah R, Kato S, Roujol S, Murthy V, Bellm S, Kashem A, Basha T, Jang J, Eisman A, Manning W, Nezafat R. Native Myocardial T1 as a Biomarker of Cardiac Structure in Non-Ischemic Cardiomyopathy. The American Journal Of Cardiology 2015, 117: 282-288. PMID: 26684511, DOI: 10.1016/j.amjcard.2015.10.046.Peer-Reviewed Original ResearchConceptsExtracellular volume fractionNative myocardial T1Nonischemic cardiomyopathyNative T1Myocardial T1Right ventricular ejection fractionMyocardial tissue compositionAtrial volume indexNative T1 timeVentricular ejection fractionDiffuse myocardial fibrosisOvert cardiovascular diseaseAssociations of native T1Myocardial tissue remodelingMyocardial T2Ejection fractionMyocardial fibrosisCardiac structureMultivariable adjustmentMyocardial segmentsLVEFMyocardial structureNon-ischemicVolume indexCardiovascular disease