Featured Publications
Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma
Benson M, Eisman A, Tahir U, Katz D, Deng S, Ngo D, Robbins J, Hofmann A, Shi X, Zheng S, Keyes M, Yu Z, Gao Y, Farrell L, Shen D, Chen Z, Cruz D, Sims M, Correa A, Tracy R, Durda P, Taylor K, Liu Y, Johnson W, Guo X, Yao J, Chen Y, Manichaikul A, Jain D, Yang Q, Consortium N, Bouchard C, Sarzynski M, Rich S, Rotter J, Wang T, Wilson J, Clish C, Sarkar I, Natarajan P, Gerszten R. Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma. Cell Metabolism 2023, 35: 1646-1660.e3. PMID: 37582364, PMCID: PMC11118091, DOI: 10.1016/j.cmet.2023.07.012.Peer-Reviewed Original ResearchConceptsAssociation studiesPlasma metabolomics studyKnockout strainGene-metabolitesProtein regulationHuman geneticsProteomic determinantsHuman plasmaMendelian randomizationSignaling pathwayThyroxine-binding globulinMetabolomics studiesMR associationsProteinBioactive proteinsMetabolite levelsHuman cohortsPlasma samplesUnrecognized associationCirculating proteinsHuman metabolismBiochemical profileMetabolitesAssociationPlasma
2022
Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals
Tahir U, Katz D, Avila-Pachecho J, Bick A, Pampana A, Robbins J, Yu Z, Chen Z, Benson M, Cruz D, Ngo D, Deng S, Shi X, Zheng S, Eisman A, Farrell L, Hall M, Correa A, Tracy R, Durda P, Taylor K, Liu Y, Johnson W, Guo X, Yao J, Chen Y, Manichaikul A, Ruberg F, Blaner W, Jain D, Bouchard C, Sarzynski M, Rich S, Rotter J, Wang T, Wilson J, Clish C, Natarajan P, Gerszten R. Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals. Nature Communications 2022, 13: 4923. PMID: 35995766, PMCID: PMC9395431, DOI: 10.1038/s41467-022-32275-3.Peer-Reviewed Original ResearchConceptsGenome association studiesGenomic diversityAssociation studiesWhole-genome association studiesLocus-metabolite associationsIndividuals of European ancestryIntegrative omics approachMetabolite peaksGenetic informationCardiometabolic diseasesSpecific allelesEuropean ancestryOmics approachesSickle cell diseaseMulti-ethnic cohortTransthyretin amyloidosisAncestryHereditary diseaseIdentified metabolitesCell diseaseHuman metabolismUnknown metabolitesDiversityBlack individualsJackson Heart Study