2024
Accelerated evolution in the human lineage led to gain and loss of transcriptional enhancers in the RBFOX1 locus
Berasain L, Beati P, Trigila A, Rubinstein M, Franchini L. Accelerated evolution in the human lineage led to gain and loss of transcriptional enhancers in the RBFOX1 locus. Science Advances 2024, 10: eadl1049. PMID: 38924416, PMCID: PMC11204294, DOI: 10.1126/sciadv.adl1049.Peer-Reviewed Original ResearchConceptsTranscriptional enhancersGoal of evolutionary biologyHuman lineageZebrafish reporter assayGene regulatory networksPotential regulatory elementsHuman-specific traitsChimpanzee sequencesRBFOX1 locusRegulatory elementsRegulatory networksRegulatory modificationsEvolutionary biologyAccelerated evolutionTarget genesGene expressionGenesDevelopmental stagesLociLineagesReporter assayExpressionRBFOX1SplicingTemporal changes
2002
Thrittene, Homologous with Somatostatin-28(1–13), Is a Novel Peptide in Mammalian Gut and Circulation
Ensinck J, Baskin D, Vahl T, Vogel R, Laschansky E, Francis B, Hoffman R, Krakover J, Stamm M, Low M, Rubinstein M, Otero-Corchon V, D’Alessio D. Thrittene, Homologous with Somatostatin-28(1–13), Is a Novel Peptide in Mammalian Gut and Circulation. Endocrinology 2002, 143: 2599-2609. DOI: 10.1210/en.143.7.2599.Peer-Reviewed Original ResearchMammalian gutS-28(1-12C-terminal domainAmino acid sequenceN-terminal regionC-terminal productGI endocrine cellsSite of synthesisEndocrine cellsPROS geneS-28Acid sequenceRatios of peptidesPreprosomatostatin genesC-terminusMolecular massDistal gutGenesS-14Proximal regionGutTract of ratsGut neuronsMyenteric neuronsMammalian neurons