2001
New Perspectives on Pneumococcal Meningitis
Aronin S, Quagliarello V. New Perspectives on Pneumococcal Meningitis. Hospital Practice 2001, 36: 43-51. PMID: 11220360, DOI: 10.3810/hp.2001.02.228.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Bacterial AgentsChildHumansMeningitis, PneumococcalSpinal PunctureStreptococcus pneumoniae
1986
Morphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation.
Quagliarello V, Long W, Scheld W. Morphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation. Journal Of Clinical Investigation 1986, 77: 1084-1095. PMID: 3514671, PMCID: PMC424442, DOI: 10.1172/jci112407.Peer-Reviewed Original ResearchConceptsBlood-brain barrierH. influenzae type b.Cerebral capillary endotheliumBBB permeabilityInfection durationMorphologic alterationsCapillary endotheliumEffective blood-brain barrierInduction of meningitisLonger infection durationUnencapsulated mutant strainCerebrospinal fluid bacterial concentrationsType B.Significant increaseIntercellular tight junctionsBBB injuryMeningitis inductionMeningeal pathogensExperimental meningitisHost clearanceCSF clearanceMeningitisMorphologic changesMorphologic explanationProgressive increase