2021
12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka
Jayasundara D, Senavirathna I, Warnasekara J, Gamage C, Siribaddana S, Kularatne SAM, Matthias M, Mariet JF, Picardeau M, Agampodi S, Vinetz J. 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka. PLOS Neglected Tropical Diseases 2021, 15: e0009272. PMID: 33735202, PMCID: PMC8009393, DOI: 10.1371/journal.pntd.0009272.Peer-Reviewed Original ResearchConceptsClonal groupsAcute kidney injuryL. interrogansMajor clinical challengeGlobal disease threatsLeptospira speciesL. interrogans infectionKidney injuryLiver impairmentCardiovascular involvementL. borgpeterseniiClinical presentationProspective studyClinical severityClinical challengePathogenic Leptospira speciesAnnual epidemicsUbiquitous zoonotic diseaseNew serogroupEpidemiological contextZoonotic diseaseCulture isolationLeptospiral culturesL. weiliiLeptospira diversity
2016
Severe leptospirosis and pancreatitis; A case series from a leptospirosis outbreak in Anuradhapura district, Sri Lanka
Herath NJ, Kamburapola CJ, Agampodi SB. Severe leptospirosis and pancreatitis; A case series from a leptospirosis outbreak in Anuradhapura district, Sri Lanka. BMC Infectious Diseases 2016, 16: 644. PMID: 27821124, PMCID: PMC5100107, DOI: 10.1186/s12879-016-2010-4.Peer-Reviewed Original ResearchConceptsIntensive care unitSevere leptospirosisCase seriesConclusionThis case seriesResidual organ damageAcute kidney injuryLow serum calciumAnuradhapura districtBackgroundAcute pancreatitisAbdominal painKidney injurySix patientsCommon complicationCare unitClinical presentationElevated amylaseOrgan damageRare presentationSerum calciumAcute pancreatitisCase presentationWeNeutrophilic leukocytosisMain complicationsSerum amylaseTeaching hospital
2015
Outbreak Investigation of Leptospirosis in Padaviya, Sri Lanka
Ramsey A, Rubin-Smith J, Norwich A, Katumuluwa S, Hettiarachchi A, Wimalage S, Danushka W, Madushanka T, Nadeeshani A, Thilakarathna C, Sewwandi L, Malhari T, Sirisena P, Agampodi S. Outbreak Investigation of Leptospirosis in Padaviya, Sri Lanka. Anuradhapura Medical Journal 2015, 9: 23-26. DOI: 10.4038/amj.v9i2.7532.Peer-Reviewed Original ResearchNumber of casesCases of leptospirosisDiagnosis of leptospirosisRegional Health AuthorityRenal compromiseCardiovascular symptomsClinical presentationRetrospective reviewResultsA totalSame hospitalHigh prevalenceBase hospitalHospital staffPatientsHealth authoritiesOutbreak investigationLeptospirosisTropical diseasesPrevious outbreaksHypotensionBradycardiaRecent outbreakAdmissionHospitalParticular outbreak
2014
Regional Differences of Leptospirosis in Sri Lanka: Observations from a Flood-Associated Outbreak in 2011
Agampodi SB, Dahanayaka NJ, Bandaranayaka AK, Perera M, Priyankara S, Weerawansa P, Matthias MA, Vinetz JM. Regional Differences of Leptospirosis in Sri Lanka: Observations from a Flood-Associated Outbreak in 2011. PLOS Neglected Tropical Diseases 2014, 8: e2626. PMID: 24454971, PMCID: PMC3894175, DOI: 10.1371/journal.pntd.0002626.Peer-Reviewed Original ResearchConceptsOutbreak of leptospirosisClinical presentationAcute renal failureDifferent clinical presentationsCross-sectional studyMedian bacterial loadPublic health interventionsPublic health relevanceLeptospira interrogans serovar laiRenal failureSevere thrombocytopeniaInfectious disease epidemicsDifferent Leptospira speciesEtiological causesImportant causeHealth interventionsHealth relevanceLeptospirosisTropical diseasesBacterial loadLeptospira kirschneriLeptospirosis outbreaksSerovar laiLeptospira speciesL. kirschneri
2012
Predictors of the development of myocarditis or acute renal failure in patients with leptospirosis: An observational study
Dassanayake D, Wimalaratna H, Nandadewa D, Nugaliyadda A, Ratnatunga CN, Agampodi SB. Predictors of the development of myocarditis or acute renal failure in patients with leptospirosis: An observational study. BMC Infectious Diseases 2012, 12: 4. PMID: 22243770, PMCID: PMC3292442, DOI: 10.1186/1471-2334-12-4.Peer-Reviewed Original ResearchConceptsAcute renal failureRenal failureClinical featuresMicroscopic agglutination testOdds ratioTeaching hospitalExact testComplication of leptospirosisDevelopment of myocarditisLaboratory measuresCommon clinical featuresVaried clinical presentationsProspective descriptive studyPredictors of severityFisher's exact testMann-Whitney U testLogistic regression modelsPain 6ResultsSixty-twoLaboratory parametersClinical presentationLaboratory variablesLaboratory predictorsLeptospirosis patientsCase definition