A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface
Zhao F, Tallarek A, Wang Y, Xie Y, Diemert A, Lu-Culligan A, Vijayakumar P, Kittmann E, Urbschat C, Bayo J, Arck P, Farhadian S, Dveksler G, Garcia M, Blois S. A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface. Frontiers In Immunology 2023, 14: 1196395. PMID: 37475853, PMCID: PMC10354452, DOI: 10.3389/fimmu.2023.1196395.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionPregnancy-specific glycoprotein 1SARS-CoV-2Maternal-fetal interfacePregnant womenSuccessful pregnancyGal-1Gal-3SARS-CoV-2-infected patientsAcute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemicMaternal immune systemCoronavirus 2 pandemicMaternal immune adaptationRisk of infectionΒ-galactoside-binding proteinKey alarminUninfected womenHealthy pregnancyPregnancy parametersGal-9Inflammatory processVirus infectionImmune responseGalectin signature