Residual endotoxin induces primary graft dysfunction through ischemia-reperfusion-primed alveolar macrophages
Akbarpour M, Lecuona E, Chiu S, Wu Q, Querrey M, Fernandez R, Nunez-Santana F, Sun H, Ravi S, Kurihara C, Walter JM, Joshi N, Ren Z, Roberts SC, Hauser A, Kreisel D, Li W, Chandel N, Misharin AV, Mohanakumar T, Budinger GRS, Bharat A. Residual endotoxin induces primary graft dysfunction through ischemia-reperfusion-primed alveolar macrophages. Journal Of Clinical Investigation 2020, 130: 4456-4469. PMID: 32692317, PMCID: PMC7410086, DOI: 10.1172/jci135838.Peer-Reviewed Original ResearchConceptsTissue-resident alveolar macrophagesPrimary graft dysfunctionHuman donor lungsNeutrophil recruitmentGraft dysfunctionDonor lungsBacterial pneumoniaAlveolar macrophagesBone marrow chimeric miceDonor lung injuryActivation of TLR4Blockade of TLR4MyD88-dependent mannerResidual endotoxinCoreceptor CD14Lung transplantationLung injuryNeutrophil infiltrationFatal syndromeSuccessful treatmentMouse modelChimeric miceBacterial endotoxinTLR4EndotoxinDonor-Derived Disease Transmission in Lung Transplantation
Roberts S, Ison M. Donor-Derived Disease Transmission in Lung Transplantation. Current Pulmonology Reports 2020, 9: 1-9. DOI: 10.1007/s13665-020-00245-z.Peer-Reviewed Original ResearchDonor-derived disease transmissionDonor-derived infectionDonor-derived transmissionLung transplant populationPost-transplantation outcomesCertain bacterial infectionsDisease transmissionLung transplantationRecipient screeningHCV infectionTransplant populationTransplant periodClinician awarenessDonor organsOrgan transplantationBacterial infectionsOrgan supplyInfectionPurpose of ReviewUnderstandingTransmission eventsTransplantationRiskOrgansDonorsDisease transmission events