2021
Developing a cognitive dysfunction risk score for use with opioid-dependent persons in drug treatment
Copenhaver MM, Sanborn V, Shrestha R, Mistler CB, Sullivan MC, Gunstad J. Developing a cognitive dysfunction risk score for use with opioid-dependent persons in drug treatment. Drug And Alcohol Dependence 2021, 224: 108726. PMID: 33930640, PMCID: PMC8180490, DOI: 10.1016/j.drugalcdep.2021.108726.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidCognitive DysfunctionHumansMass ScreeningMiddle AgedNeuropsychological TestsPharmaceutical PreparationsRisk FactorsROC CurveSensitivity and SpecificityConceptsMild cognitive impairmentCognitive dysfunctionRisk scoreDrug treatmentPredictors of MCIOpioid-dependent personsOpioid use disorderPredictive risk scoreMedical chart dataNeuro-cognitive impairmentResource-limited settingsChart dataDrug treatment facilitiesAddiction-related servicesLarger validation studiesPatient demographicsROC curve areaUse disordersTreatment engagementCognitive impairmentPatientsOptimal cutClinical settingLogistic regressionMCI casesPurposeful Fentanyl Use and Associated Factors among Opioid-Dependent People Who Inject Drugs
Chandra DK, Altice FL, Copenhaver MM, Zhou X, Didomizio E, Shrestha R. Purposeful Fentanyl Use and Associated Factors among Opioid-Dependent People Who Inject Drugs. Substance Use & Misuse 2021, 56: 979-987. PMID: 33769199, DOI: 10.1080/10826084.2021.1901931.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidConnecticutCross-Sectional StudiesFentanylHumansOpioid-Related DisordersPharmaceutical PreparationsSubstance Abuse, IntravenousConceptsOpioid-dependent PWIDFentanyl useOpioid-dependent peopleIndependent correlatesSevere depressionSex-related risk behaviorsMethadone-maintained patientsMultivariable logistic regressionOpioid-related mortalityRecent cocaine useCross-sectional surveySelf-reported drugMethadone dosageYoung PWIDDaily injectionsMethadone clinicsAssociated FactorsFentanyl exposureHigh prevalencePWIDSynthetic opioidsCocaine useYounger ageRisk behaviorsLogistic regressionUse of Pre-exposure Prophylaxis Among People Who Inject Drugs: Exploratory Findings of the Interaction Between Race, Homelessness, and Trust
Zhou X, Altice FL, Chandra D, Didomizio E, Copenhaver MM, Shrestha R. Use of Pre-exposure Prophylaxis Among People Who Inject Drugs: Exploratory Findings of the Interaction Between Race, Homelessness, and Trust. AIDS And Behavior 2021, 25: 3743-3753. PMID: 33751313, DOI: 10.1007/s10461-021-03227-7.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsCross-Sectional StudiesHIV InfectionsHumansIll-Housed PersonsPharmaceutical PreparationsPre-Exposure ProphylaxisSubstance Abuse, IntravenousTrustConceptsPre-exposure prophylaxisPrEP useProvider trustPatient-level factorsOpioid-dependent patientsLogistic regression analysisNon-homeless participantsHomeless participantsRace/ethnicityEligibility criteriaCross-sectional dataPrEPProphylaxisMethadoneRegression analysisDrugsExploratory findingsParticipantsPotential moderatorsPWIDPatientsSignificant moderatorWillingness to initiate pre-exposure prophylaxis (PrEP) and its use among opioid-dependent individuals in drug treatment
Ni Z, Altice FL, Wickersham JA, Copenhaver MM, DiDomizio EE, Nelson LE, Shrestha R. Willingness to initiate pre-exposure prophylaxis (PrEP) and its use among opioid-dependent individuals in drug treatment. Drug And Alcohol Dependence 2021, 219: 108477. PMID: 33422864, PMCID: PMC7946167, DOI: 10.1016/j.drugalcdep.2020.108477.Peer-Reviewed Original ResearchConceptsOpioid-dependent individualsPre-exposure prophylaxisPrEP useHIV riskHealthcare providersSex-related risk behaviorsMultivariable logistic regression analysisAwareness of PrEPUrban methadone clinicMultiple logistic regressionDisproportionate HIV burdenLogistic regression analysisCross-sectional surveyHIV burdenHIV infectionHIV testingIndependent correlatesMethadone clinicsDrug treatmentRisk behaviorsLogistic regressionPrEPPrevious useHigher likelihoodProphylaxis
2020
The Pre-exposure Prophylaxis (PrEP) Care Cascade in People Who Inject Drugs: A Systematic Review
Mistler CB, Copenhaver MM, Shrestha R. The Pre-exposure Prophylaxis (PrEP) Care Cascade in People Who Inject Drugs: A Systematic Review. AIDS And Behavior 2020, 25: 1490-1506. PMID: 32749627, PMCID: PMC7858689, DOI: 10.1007/s10461-020-02988-x.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsHIV InfectionsHumansPharmaceutical PreparationsPre-Exposure ProphylaxisSubstance Abuse, IntravenousConceptsPre-exposure prophylaxisCare cascadeSystematic reviewInjection drug useTransmission of HIVKey risk factorsPrEP eligibilityPrEP carePrEP uptakeHIV incidenceHIV transmissionRisk factorsPRISMA guidelinesPrevention strategiesPWIDDrug useLiterature searchEfficacious strategyProphylaxisPrEPDrugsInterventionHigh awarenessHIVReviewAwareness about and willingness to use long-acting injectable pre-exposure prophylaxis (LAI-PrEP) among people who use drugs
Shrestha R, DiDomizio EE, Kim RS, Altice FL, Wickersham JA, Copenhaver MM. Awareness about and willingness to use long-acting injectable pre-exposure prophylaxis (LAI-PrEP) among people who use drugs. Journal Of Substance Use And Addiction Treatment 2020, 117: 108058. PMID: 32811633, PMCID: PMC7438607, DOI: 10.1016/j.jsat.2020.108058.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsFemaleHIV InfectionsHomosexuality, MaleHumansMalePatient Acceptance of Health CarePharmaceutical PreparationsPre-Exposure ProphylaxisThailandConceptsPre-exposure prophylaxisInjectable pre-exposure prophylaxisLAI-PrEPOral pre-exposure prophylaxisLong-term side effectsSelf-reported HIV risk behaviorsBangkok Tenofovir StudyEvidence-based HIVHigh-risk PWUDImportant key populationHIV-negative peopleOpioid use disorderHIV risk behaviorsHIV prevention effortsAddiction treatment programsDaily PrEPOral PrEPAdherence challengesIndependent correlatesFemale sexClinical trialsHIV preventionIndependent factorsSide effectsUse disorders
2019
Online HIV information seeking and pre-exposure prophylaxis awareness among people who use drugs
Ranjit YS, Shrestha R, Copenhaver M, Altice FL. Online HIV information seeking and pre-exposure prophylaxis awareness among people who use drugs. Journal Of Substance Use And Addiction Treatment 2019, 111: 16-22. PMID: 32087834, PMCID: PMC7039922, DOI: 10.1016/j.jsat.2019.12.010.Peer-Reviewed Original ResearchMeSH KeywordsCross-Sectional StudiesHIV InfectionsHumansInformation Seeking BehaviorPharmaceutical PreparationsPre-Exposure ProphylaxisSubstance Abuse, IntravenousConceptsHuman immunodeficiency virusHIV informationMethadone treatmentPre-exposure prophylaxis (PrEP) awarenessPre-exposure prophylaxisNew HIV diagnosesHIV-negative PWUDBehavior change continuumCross-sectional surveyMethods of preventionAddiction treatment programsHIV diagnosisImmunodeficiency virusInjection drugsHIV preventionHigh riskGeneral populationSex partnersOverall healthTreatment programPrEPDrugsPWUDChange continuumRisk