2020
Clinical impact of rapid influenza PCR in the adult emergency department on patient management, ED length of stay, and nosocomial infection rate
Peaper DR, Branson B, Parwani V, Ulrich A, Shapiro MJ, Clemons C, Campbell M, Owen M, Martinello RA, Landry ML. Clinical impact of rapid influenza PCR in the adult emergency department on patient management, ED length of stay, and nosocomial infection rate. Influenza And Other Respiratory Viruses 2020, 15: 254-261. PMID: 32851793, PMCID: PMC7902247, DOI: 10.1111/irv.12800.Peer-Reviewed Original ResearchConceptsEmergency departmentInfluenza PCRPatient managementClinical redesignED lengthInfluenza seasonED workflowPCR testingBed transfersAnti-influenza medicationsDiverse emergency departmentsHospital-acquired influenzaInfluenza-positive patientsHA influenzaNosocomial infection ratesDiagnosis of influenzaAdult emergency departmentAnti-viral therapyCommon presenting concernPost-intervention periodPre-post studyED LOSED patientsSignificant morbidityTherapeutic guidelines
2018
Detection of Influenza A and B Viruses and Respiratory Syncytial Virus by Use of Clinical Laboratory Improvement Amendments of 1988 (CLIA)-Waived Point-of-Care Assays: a Paradigm Shift to Molecular Tests
Azar MM, Landry ML. Detection of Influenza A and B Viruses and Respiratory Syncytial Virus by Use of Clinical Laboratory Improvement Amendments of 1988 (CLIA)-Waived Point-of-Care Assays: a Paradigm Shift to Molecular Tests. Journal Of Clinical Microbiology 2018, 56: 10.1128/jcm.00367-18. PMID: 29695519, PMCID: PMC6018333, DOI: 10.1128/jcm.00367-18.BooksConceptsRapid influenza diagnostic testsRespiratory syncytial virusNucleic acid amplification testsSyncytial virusB virusInfluenza AClinical Laboratory Improvement AmendmentsAntiviral therapyPoint of careAvailable rapid influenza diagnostic testsSensitive nucleic acid amplification testsMolecular testsInfluenza diagnostic testsRespiratory virus infectionsInfection prevention strategiesRapid antigen detectionRapid laboratory testingViral diagnostic testingDetection of influenzaNew pandemic strainsAccurate laboratory diagnosisRapid antigenRespiratory virusesViral culturePatient management
2008
Real-time PCR compared to Binax NOW and cytospin-immunofluorescence for detection of influenza in hospitalized patients
Landry ML, Cohen S, Ferguson D. Real-time PCR compared to Binax NOW and cytospin-immunofluorescence for detection of influenza in hospitalized patients. Journal Of Clinical Virology 2008, 43: 148-151. PMID: 18639488, PMCID: PMC7173065, DOI: 10.1016/j.jcv.2008.06.006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntibodies, MonoclonalChildChild, PreschoolFluorescent Antibody Technique, DirectHospitalizationHumansImmunoassayInfantInfluenza A virusInfluenza B virusInfluenza, HumanMiddle AgedNasopharynxReagent Kits, DiagnosticReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionSensitivity and SpecificityTaq PolymeraseTime FactorsVirus CultivationYoung AdultConceptsHospitalized patientsTaqMan RT-PCRRT-PCRInfluenza ARapid flu testsDiagnosis of influenzaInfluenza-positive samplesDetection of influenzaReal-time RT-PCRInfluenza BInfluenza diagnosisPatient managementReal-time PCRMore accurate testsPatientsBinaxTrue positive samplesRapid testClinical samplesPositive samplesFurther studiesHospitalAccurate testInfluenzaDiagnosis
2003
Comparison of SmartCycler Real-Time Reverse Transcription-PCR Assay in a Public Health Laboratory with Direct Immunofluorescence and Cell Culture Assays in a Medical Center for Detection of Influenza A Virus
Habib-Bein NF, Beckwith WH, Mayo D, Landry ML. Comparison of SmartCycler Real-Time Reverse Transcription-PCR Assay in a Public Health Laboratory with Direct Immunofluorescence and Cell Culture Assays in a Medical Center for Detection of Influenza A Virus. Journal Of Clinical Microbiology 2003, 41: 3597-3601. PMID: 12904361, PMCID: PMC179819, DOI: 10.1128/jcm.41.8.3597-3601.2003.Peer-Reviewed Original ResearchConceptsVirus-positive specimensDirect immunofluorescence antibody stainingPublic health laboratoriesHealth laboratoriesRT-PCRMedical CenterRapid diagnosisYale-New Haven HospitalReal-time RT-PCRResults of cultureRhesus monkey kidney cell culturesImmunofluorescence antibody stainingReal-time reverse transcriptionInfluenza A virusesMonkey kidney cell culturesConventional RT-PCR analysisReal-time RT-PCR systemRespiratory specimensInfluenza APatient managementDirect immunofluorescenceCell culturesKidney cell culturesRapid turnaround timeA virus
2000
SimulFluor Respiratory Screen for Rapid Detection of Multiple Respiratory Viruses in Clinical Specimens by Immunofluorescence Staining
Landry M, Ferguson D. SimulFluor Respiratory Screen for Rapid Detection of Multiple Respiratory Viruses in Clinical Specimens by Immunofluorescence Staining. Journal Of Clinical Microbiology 2000, 38: 708-711. PMID: 10655371, PMCID: PMC86182, DOI: 10.1128/jcm.38.2.708-711.2000.Peer-Reviewed Original ResearchConceptsCommon respiratory virusesRespiratory virusesMultiple respiratory virusesVirus isolatesRespiratory samplesPatient managementDirect immunofluorescenceInfection controlClinical specimensCytospin preparationsVirusScreening reagentImmunofluorescenceCell culturesSample collectionGreat benefitIsolates
1994
Multiple viral infections in the immunocompromised host: recognition and interpretation
Landry M. Multiple viral infections in the immunocompromised host: recognition and interpretation. Journal Of Clinical Virology 1994, 2: 313-321. PMID: 15566777, DOI: 10.1016/0928-0197(94)90001-9.Peer-Reviewed Original ResearchMultiple viral infectionsViral infectionClinical findingsPatient's clinical findingsMultiple test modalitiesImmunocompromised hostEarly recognitionImmunodeficient hostsConcurrent infectionPatient managementSame body siteVirus infectionTransient infectionMultiple virus infectionsLatent infectionCommon virusesBody sitesInfectionSpecimen sourceLaboratory recognitionLaboratory test resultsMore virusesCareful evaluationTest modalitiesMultiple viruses