2020
Invasive pseudomembranous upper airway and tracheal Aspergillosis refractory to systemic antifungal therapy and serial surgical debridement in an Immunocompetent patient
Khan SN, Manur R, Brooks JS, Husson MA, Leahy K, Grant M. Invasive pseudomembranous upper airway and tracheal Aspergillosis refractory to systemic antifungal therapy and serial surgical debridement in an Immunocompetent patient. BMC Infectious Diseases 2020, 20: 13. PMID: 31906888, PMCID: PMC6945574, DOI: 10.1186/s12879-019-4744-2.Peer-Reviewed Case Reports and Technical NotesConceptsImmunocompetent patientsEndoscopic debridementLong-term antibiotic treatmentComplete disease resolutionSystemic antifungal therapySerial surgical debridementEfficacious treatment approachVoriconazole dosingRefractory symptomsSymptom controlAggressive treatmentBacterial sinusitisDisease resolutionRespiratory symptomsSurgical debridementRespiratory infectionsVoriconazole monotherapyTreatment regimensFungal infiltrationMechanical debridementUpper airwayAntibiotic treatmentAntifungal therapyDisease progressionSuch infections
2019
Slowly progressive fatal PML-IRIS following antiretroviral initiation at CD4+ nadir of 350 cells/mm3 despite CD4+ cell count rise to 900 cells/mm3
Sandhu MR, Rutledge R, Grant M, Mahajan A, Spudich S. Slowly progressive fatal PML-IRIS following antiretroviral initiation at CD4+ nadir of 350 cells/mm3 despite CD4+ cell count rise to 900 cells/mm3. International Journal Of STD & AIDS 2019, 30: 810-813. PMID: 31046614, DOI: 10.1177/0956462419835966.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAntiretroviral Therapy, Highly ActiveBrainCD4 Lymphocyte CountDisease ProgressionDystonic DisordersFatal OutcomeHIV InfectionsHumansImmune Reconstitution Inflammatory SyndromeJC VirusLeukoencephalopathy, Progressive MultifocalMagnetic Resonance ImagingMaleTreatment OutcomeConceptsImmune reconstitution inflammatory syndromePML-IRISAntiretroviral therapyCell countInflammatory syndromeInitiation of ARTHIV/AIDS patientsReconstitution inflammatory syndromeRobust immune reconstitutionCells/mm3Progressive multifocal leukoencephalopathyRole of CD4Blood-brain barrierCells/Antiretroviral initiationInflammatory picturePersistent positivityImmune reconstitutionMultifocal leukoencephalopathyNeurological symptomsOpportunistic infectionsAIDS patientsVirus antigenImmune responseJC virus