Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study
van Duin D, Arias C, Komarow L, Chen L, Hanson B, Weston G, Cober E, Garner O, Jacob J, Satlin M, Fries B, Garcia-Diaz J, Doi Y, Dhar S, Kaye K, Earley M, Hujer A, Hujer K, Domitrovic T, Shropshire W, Dinh A, Manca C, Luterbach C, Wang M, Paterson D, Banerjee R, Patel R, Evans S, Hill C, Arias R, Chambers H, Fowler V, Kreiswirth B, Bonomo R, Investigators M. Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study. The Lancet Infectious Diseases 2020, 20: 731-741. PMID: 32151332, PMCID: PMC7473597, DOI: 10.1016/s1473-3099(19)30755-8.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarbapenem-Resistant EnterobacteriaceaeCohort StudiesEnterobacteriaceae InfectionsFemaleHumansMaleMiddle AgedPhylogenyProspective StudiesUnited StatesConceptsCarbapenem-resistant EnterobacteralesCarbapenemase-producing EnterobacteralesCohort studyProspective cohort studyCRE infectionsIndex culturePrimary outcomeK pneumoniaeCRE groupAdmission ratesClinical dataClinical epidemiologyClinical culturesPatientsUS hospitalsDay 107Similar outcomesDisease controlDesirability of outcomeEnterobacteralesUnique isolatesNational InstituteOutcomesWhole-genome sequencingInfection