Dysregulation of sterol regulatory element-binding protein 2 gene in HIV treatment-experienced individuals
Sopeyin A, Zhou L, Li M, Barakat L, Paintsil E. Dysregulation of sterol regulatory element-binding protein 2 gene in HIV treatment-experienced individuals. PLOS ONE 2019, 14: e0226573. PMID: 31846498, PMCID: PMC6917281, DOI: 10.1371/journal.pone.0226573.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnti-HIV AgentsBiological TransportCholesterolFemaleGene Expression RegulationHIV InfectionsHumansMaleMiddle AgedRNA, MessengerSterol Regulatory Element Binding Protein 2ConceptsTreatment-experienced individualsAntiretroviral therapyCholesterol biosynthesis genesSide effectsEffect of ARTLow density lipoprotein receptor pathwayHIV viral suppressionCase-control studyLipoprotein receptor pathwaySterol regulatory element-binding protein 2Cassette transporter A1Protein expression levelsViral suppressionLipid abnormalitiesClinical manifestationsMetabolic derangementsCardiovascular diseaseRetrospective analysisTherapeutic benefitProtein 2 geneMRNA expressionReceptor pathwayMarked decreaseDysregulationExpression levels