2007
Marginal Zone B-Cell Depletion Impairs Murine Host Defense against Borrelia burgdorferi Infection
Belperron AA, Dailey CM, Booth CJ, Bockenstedt LK. Marginal Zone B-Cell Depletion Impairs Murine Host Defense against Borrelia burgdorferi Infection. Infection And Immunity 2007, 75: 3354-3360. PMID: 17470546, PMCID: PMC1932939, DOI: 10.1128/iai.00422-07.Peer-Reviewed Original ResearchConceptsT-cell-independent antibodiesCell-depleted miceSplenic CD4Cell depletionPathogen burdenSplenic T cell responsesHost defenseT-cell activation markersC3H/HeJ miceImmunoglobulin M titersInfected control miceMurine host defensePathogen-specific IgMT cell responsesMarginal zone B cellsBlood-borne antigensBlood-borne pathogensWeeks of infectionB cell subsetsImmune mouse serumBorrelia burgdorferi infectionImportant host defenseSevere arthritisActivation markersControl mice
2001
Natural Antibody Affects Survival of the SpirocheteBorrelia burgdorferi within Feeding Ticks
Belperron A, Bockenstedt L. Natural Antibody Affects Survival of the SpirocheteBorrelia burgdorferi within Feeding Ticks. Infection And Immunity 2001, 69: 6456-6462. PMID: 11553590, PMCID: PMC98781, DOI: 10.1128/iai.69.10.6456-6462.2001.Peer-Reviewed Original ResearchConceptsB cell-deficient miceNatural antibodiesControl miceConfocal immunofluorescence microscopySalivary glandsEarly host defenseBlood-sucking vectorsMammalian hostsFeeding ticksB. burgdorferi organismsNormal mouse serumTick midgutAbsence of exposureOuter surface protein AArthropod vectorsImmunofluorescence microscopyMammalian seraSurface protein ASpirochete Borrelia burgdorferiPolyclonal immunoglobulin MPathogen transmissionSpirochete burdenPassive transferBlood mealImmunoglobulin MCD4+ T Helper 1 Cells Facilitate Regression of Murine Lyme Carditis
Bockenstedt L, Kang I, Chang C, Persing D, Hayday A, Barthold S. CD4+ T Helper 1 Cells Facilitate Regression of Murine Lyme Carditis. Infection And Immunity 2001, 69: 5264-5269. PMID: 11500394, PMCID: PMC98634, DOI: 10.1128/iai.69.9.5264-5269.2001.Peer-Reviewed Original ResearchConceptsAlphabeta T-cell-deficient miceT cell-deficient miceMurine Lyme carditisT cellsLyme carditisB cellsT helper 1 cellsAnti-inflammatory cytokines mRNA levelsTumor necrosis factor alphaBurgdorferi-specific antibodiesInfected control miceProminent macrophage infiltrateCell-mediated immunityT cell responsesT helper 1Murine Lyme borreliosisCytokine mRNA levelsNecrosis factor alphaAlphabeta T cellsPrincipal immune cellsMouse strain backgroundAdoptive transferAcute arthritisMacrophage infiltratesControl mice
2000
Cutting Edge: CD1d Deficiency Impairs Murine Host Defense Against the Spirochete, Borrelia burgdorferi
Kumar H, Belperron A, Barthold S, Bockenstedt L. Cutting Edge: CD1d Deficiency Impairs Murine Host Defense Against the Spirochete, Borrelia burgdorferi. The Journal Of Immunology 2000, 165: 4797-4801. PMID: 11046002, DOI: 10.4049/jimmunol.165.9.4797.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialAntigens, BacterialAntigens, CD1Antigens, CD1dAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferi GroupDNA, BacterialGenetic Predisposition to DiseaseImmunity, InnateImmunoglobulin GLipoproteinsLyme DiseaseLyme Disease VaccinesMiceMice, Inbred C3HMice, Inbred C57BLMice, KnockoutUrinary BladderConceptsLipid AgsHost defenseCD1d-deficient miceDisease-susceptible miceMurine host defenseRole of CD1dImpair host resistanceBorrelia burgdorferiSusceptible mouse strainsControl miceT cellsCD1 moleculesSpirochete DNADisease profileMouse strainsMiceLyme disease spirocheteInfectionSpirochetesBurgdorferiHost resistancePathogensArthritisCD1dEnhanced production