Stavudine Resistance: An Update on Susceptibility following Prolonged Therapy
Lin P, González C, Griffith B, Friedland G, Calvez V, Ferchal F, Schinazi R, Shepp D, Ashraf A, Wainberg M, Soriano V, Mellors J, Colonno R. Stavudine Resistance: An Update on Susceptibility following Prolonged Therapy. Antiviral Therapy 1999, 4: 21-28. PMID: 10682125, DOI: 10.1177/135965359900400103.Peer-Reviewed Original ResearchConceptsPost-treatment isolatesStavudine resistanceStavudine therapyFirst-line combination therapyAmino acid changesUse of stavudineMonths of treatmentClinical HIV-1HIV-1 strainsNucleoside analoguesAcid changesProlonged therapyHIV patientsConsistent amino acid changesCombination therapyMulti-resistant phenotypeHIV-1Lower incidenceReverse transcriptase geneClinical isolatesTherapyDrug sensitivityPatientsTranscriptase geneCurrent report