2024
Associations Between Reductions in Depressive Symptoms and Reductions in Pain and Anxiety Symptoms and Substance Use: Emulation of a Randomized Trial
Khan M, Acri M, Ban K, Scheidell J, Stevens E, Manandhar-Sasaki P, Charles D, Chichetto N, Crystal S, Gordon A, Marshall B, Edelman E, Justice A, Braithwaite S, Caniglia E. Associations Between Reductions in Depressive Symptoms and Reductions in Pain and Anxiety Symptoms and Substance Use: Emulation of a Randomized Trial. AJPM Focus 2024, 3: 100258. PMID: 39290574, PMCID: PMC11407062, DOI: 10.1016/j.focus.2024.100258.Peer-Reviewed Original ResearchUnhealthy alcohol useDepressive symptomsAnxiety symptomsIllicit opioid useOdds ratioAlcohol useVeterans Aging Cohort StudyPain symptomsConfidence intervalsTarget trial emulation frameworkElevated depressive symptomsAssociated with reductionsReducing depressive symptomsAging Cohort StudySubstance useOpioid useMultisite observational studyDepressive symptom reductionNext follow-up visitUS veteransReduce painFollow-up visitCohort studyAntidepressant medicationComparing individuals
2023
Implementing Programs to Initiate Buprenorphine for Opioid Use Disorder Treatment in High-Need, Low-Resource Emergency Departments: A Nonrandomized Controlled Trial
McCormack R, Rotrosen J, Gauthier P, D'Onofrio G, Fiellin D, Marsch L, Novo P, Liu D, Edelman E, Farkas S, Matthews A, Mulatya C, Salazar D, Wolff J, Knight R, Goodman W, Williams J, Hawk K. Implementing Programs to Initiate Buprenorphine for Opioid Use Disorder Treatment in High-Need, Low-Resource Emergency Departments: A Nonrandomized Controlled Trial. Annals Of Emergency Medicine 2023, 82: 272-287. PMID: 37140493, PMCID: PMC10524047, DOI: 10.1016/j.annemergmed.2023.02.013.Peer-Reviewed Original ResearchConceptsBuprenorphine programImplementation facilitationEmergency departmentMedical recordsOpioid use disorder treatmentMain secondary outcomesMore treatment visitsPrimary implementation outcomeNonrandomized Controlled TrialPatient-level outcomesPatients' medical recordsUse disorder treatmentTreatment 30 daysBuprenorphine administrationOpioid useSecondary outcomesControlled TrialsTreatment visitsED settingUnique patientsClinicians' readinessEligibility criteriaClinical protocolsDisorder treatmentOverdose eventsHomelessness and Treatment Outcomes Among Black Adults With Opioid Use Disorder: A Secondary Analysis of X:BOT
Justen M, Scodes J, Pavlicova M, Choo T, Gopaldas M, Haeny A, Opara O, Rhee T, Rotrosen J, Nunes E, Hawk K, Edelman E. Homelessness and Treatment Outcomes Among Black Adults With Opioid Use Disorder: A Secondary Analysis of X:BOT. Journal Of Addiction Medicine 2023, 17: 463-467. PMID: 37579110, PMCID: PMC10323031, DOI: 10.1097/adm.0000000000001125.Peer-Reviewed Original ResearchConceptsClinical trialsTreatment outcomesSecondary analysisOpioid use disorder treatmentBlack individualsExtended-release naltrexoneOpioid use disorderAdditional clinical supportBlack participantsUse disorder treatmentBuprenorphine-naloxoneStudy medicationWeeks postrandomizationMedication initiationClinical characteristicsOpioid useTrial entryUrine toxicologyBlack patientsSedative useExtramedical useUse disordersClinical supportDisorder treatmentBlack adults
2022
Cessation of self-reported opioid use and impacts on co-occurring health conditions
Scheidell J, Townsend T, Ban K, Caniglia E, Charles D, Edelman E, Marshall B, Gordon A, Justice A, Braithwaite R, Khan M. Cessation of self-reported opioid use and impacts on co-occurring health conditions. Drug And Alcohol Dependence 2022, 242: 109712. PMID: 36469994, PMCID: PMC10108375, DOI: 10.1016/j.drugalcdep.2022.109712.Peer-Reviewed Original ResearchConceptsOpioid useCocaine useSelf-reported opioid useBaseline opioid useCo-occurring health conditionsUnhealthy alcohol useEvidence-based interventionsLogistic regression modelsOpioid misusePrescription opioidsSelf-reported useReporting cannabisDepressive symptomsPainCannabis useAlcohol useHealth conditionsSubstance useSymptomsAnxiety symptomsSubsequent cessationCessationRegression modelsOutcomesParticipantsOutcomes of Patients with Opioid-Related Diagnoses in Acute Coronary Syndrome: a National Inpatient Sample-Based Analysis
Kim Y, Pacor J, Do A, Brennan J, Fiellin D, Edelman E. Outcomes of Patients with Opioid-Related Diagnoses in Acute Coronary Syndrome: a National Inpatient Sample-Based Analysis. Journal Of General Internal Medicine 2022, 38: 563-570. PMID: 36376632, PMCID: PMC9971420, DOI: 10.1007/s11606-022-07399-3.Peer-Reviewed Original ResearchConceptsOpioid-related diagnosesPercutaneous coronary interventionCardiac arrestHospital mortalityCoronary syndromeNational Inpatient Sample databaseManagement of ACSRisk of ACSCardiovascular risk factorsOutcomes of patientsAcute coronary syndromeProportion of patientsMultivariable logistic regressionNational Inpatient SampleHospital cardiac arrestRisk of mortalityBackgroundAcute coronary syndromeOutcomes of interestT-testStudent's t-testPrimary independent variableHospital outcomesACS managementCoronary interventionOpioid use
2020
All-cause mortality among males living with and without HIV initiating long-term opioid therapy, and its association with opioid dose, opioid interruption and other factors
Gordon K, Manhapra A, Crystal S, Dziura J, Edelman E, Skanderson M, Kerns R, Justice A, Tate J, Becker W. All-cause mortality among males living with and without HIV initiating long-term opioid therapy, and its association with opioid dose, opioid interruption and other factors. Drug And Alcohol Dependence 2020, 216: 108291. PMID: 33011662, PMCID: PMC7644145, DOI: 10.1016/j.drugalcdep.2020.108291.Peer-Reviewed Original ResearchConceptsMorphine equivalent daily doseCause mortalityLong-term opioid therapyTime-updated Cox regressionStrong dose-response relationshipUnnatural deathsEquivalent daily doseDose-response relationshipOpioid doseOpioid therapyUninfected patientsOpioid useDaily doseCox regressionMortality outcomesTherapy doseHigh doseMale veteransOverdose fatalitiesOverdose mortalityPLWHMortalityHIVPatientsDoseOpioid Overdose Prevention Education for Medical Students: Adopting Harm Reduction into Mandatory Clerkship Curricula
Oldfield BJ, Tetrault JM, Wilkins KM, Edelman EJ, Capurso NA. Opioid Overdose Prevention Education for Medical Students: Adopting Harm Reduction into Mandatory Clerkship Curricula. Substance Use & Addiction Journal 2020, 41: 29-34. PMID: 31211657, DOI: 10.1080/08897077.2019.1621241.Peer-Reviewed Original ResearchConceptsHarm reduction theoryOpioid overdosesOverdose educationOpioid overdose prevention educationHarm reductionEducational interventionLow knowledgeOverdose prevention educationOpioid overdose deathsNaloxone distribution programsPublic health crisisOpioid useMedical studentsOverdose deathsOverdose preventionOverdosesModerate improvementPrevention educationNaloxoneClerkship medical studentsHealth crisisDistribution programWeeksInterventionStudents' knowledge
2019
Marijuana Use Is Not Associated With Changes in Opioid Prescriptions or Pain Severity Among People Living With HIV and Chronic Pain.
Merlin JS, Long D, Becker WC, Cachay ER, Christopolous KA, Claborn KR, Crane HM, Edelman E, Lovejoy TI, Mathews WC, Morasco BJ, Napravnik S, OʼCleirigh C, Saag MS, Starrels JL, Gross R, Liebschutz JM. Marijuana Use Is Not Associated With Changes in Opioid Prescriptions or Pain Severity Among People Living With HIV and Chronic Pain. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 81: 231-237. PMID: 30865181, PMCID: PMC6522289, DOI: 10.1097/qai.0000000000001998.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidChronic PainFemaleFollow-Up StudiesHIV InfectionsHumansLogistic ModelsMaleMarijuana SmokingMarijuana UseMedical MarijuanaMiddle AgedMultivariate AnalysisOpioid-Related DisordersPrescription DrugsProspective StudiesSelf ReportSurveys and QuestionnairesTreatment OutcomeUnited StatesConceptsChronic painPain severityIndex visitOpioid useMultivariable binary logistic regression modelMarijuana useDiscontinuation of opioidsImproved pain outcomesMedian pain severityAIDS Research NetworkPrescription opioid usePrescribed opioid useIntegrated Clinical SystemsLogistic regression modelsBinary logistic regression modelOpioid discontinuationOpioid initiationOpioid prescribingOpioid prescriptionsPain outcomesClinical systemsHigher oddsLower oddsPainPLWHIntegration of care for HIV and opioid use disorder
Oldfield B, Muñoz N, McGovern M, Funaro M, Villanueva M, Tetrault J, Edelman E. Integration of care for HIV and opioid use disorder. AIDS 2019, Publish Ahead of Print: &na;. PMID: 30882491, PMCID: PMC6588508, DOI: 10.1097/qad.0000000000002125.Peer-Reviewed Original ResearchConceptsHIV care settingsCare settingsClinical benefitTreatment settingsSystematic reviewBuprenorphine/naloxoneOpioid use disorderProvision of medicationsIntegration of careAntiretroviral therapyOpioid useMedication adherencePROSPERO databaseOvid MEDLINETreatment strategiesObservational studyHIVUse disordersModerate riskBehavioral interventionsScreening strategyOUDRisk reductionTreatmentUnique studies