2008
Predictors of lethality in severe leptospirosis in urban Brazil.
Spichler AS, Vilaça PJ, Athanazio DA, Albuquerque JO, Buzzar M, Castro B, Seguro A, Vinetz JM. Predictors of lethality in severe leptospirosis in urban Brazil. American Journal Of Tropical Medicine And Hygiene 2008, 79: 911-4. PMID: 19052303, PMCID: PMC2640419, DOI: 10.4269/ajtmh.2008.79.911.Peer-Reviewed Original ResearchConceptsSevere leptospirosisRetrospective case-control studyPopulation-based surveillance dataDevelopment of oliguriaPredictors of deathStrong risk factorCase-control studyPredictors of lethalityDeath certificate reportingLung involvementPulmonary involvementPrognostic factorsSerologic findingsFatal outcomePatient hospitalizationRisk factorsSurvivor casesOdds ratioLethal casesHigh titersLeptospirosis casesSurveillance dataLeptospira interrogansLeptospirosisHospitalization
2007
Reversal of renal tubule transporter downregulation during severe leptospirosis with antimicrobial therapy.
Spichler A, Ko AI, Silva EF, De Brito T, Silva AM, Athanazio D, Silva C, Seguro A. Reversal of renal tubule transporter downregulation during severe leptospirosis with antimicrobial therapy. American Journal Of Tropical Medicine And Hygiene 2007, 77: 1111-9. PMID: 18165532, DOI: 10.4269/ajtmh.2007.77.1111.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAmpicillinAnimalsAnti-Bacterial AgentsAntigens, BacterialCricetinaeDown-RegulationFemaleFree Radical ScavengersGene Expression ProfilingGene Expression RegulationKidneyLiverMesocricetusSodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersSodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 1ThiobarbituratesWeil DiseaseConceptsSevere leptospirosisAntimicrobial therapyN-acetylcysteineSerum thiobarbituric acidEvidence of benefitThick ascending limbNKCC2 transportersRenal involvementRenal expressionTubular dysfunctionAntioxidant therapyInfected hamstersTubular defectsNAC effectAscending limbAmpicillin treatmentRenal transportersTherapyTarget tissuesLeptospiral antigensAMP treatmentType 3Reduced levelsTransporter downregulationNormal expression