Chronic Kidney Disease in Children
Overview
Progression of chronic kidney disease (CKD) in children leads to end stage kidney disease (ESKD), which is associated with mortality rates 30-150 times higher than the general pediatric population. The traditional biomarkers, serum creatinine and proteinuria, are used to predict progression of CKD in clinical trials even though both correlate poorly with the progression of CKD and the response to interventions.
We aim to identify the optimal combination of novel biomarkers which best predict progression of CKD in children. We plan to measure urine and blood biomarkers of kidney injury, inflammation, repair, and fibrosis from the samples of the children enrolled in the CKD in Children (CKiD) cohort and Assessment, Serial Evaluation, and Subsequent Sequelae in AKI (ASSESS-AKI) cohort studies. Using biomarkers that represent the multifactorial pathophysiology of CKD progression, we will be able to quantify the spectrum of kidney injury.
Contact Information
For more information, or if you are interested in collaborating on this study, please contact Dr. Jason Greenberg
Leadership
Collaborators
Susan L. Furth, MD, PhD
Children's Hospital of Philadelphia
Prasad Devarajan, MD
Cincinnati Children's Hospital
Michael Zappitelli, MD, M.Sc.
The Hospital for Sick Children (Toronto, ON)
Publications
- Urine Biomarkers of Kidney Tubule Health, Injury, and Inflammation are Associated with Progression of CKD in Children.Greenberg JH, Abraham AG, Xu Y, Schelling JR, Feldman HI, Sabbisetti VS, Ix JH, Jogalekar MP, Coca S, Waikar SS, Shlipak MG, Warady BA, Vasan RS, Kimmel PL, Bonventre JV, Denburg M, Parikh CR, Furth S. J Am Soc Nephrol. 2021 Oct; 2021 Sep 20. PMID: 34544821.
- Long-Term Kidney Outcomes Following Dialysis-Treated Childhood Acute Kidney Injury: A Population-Based Cohort Study.Robinson CH, Jeyakumar N, Luo B, Wald R, Garg AX, Nash DM, McArthur E, Greenberg JH, Askenazi D, Mammen C, Thabane L, Goldstein S, Parekh RS, Zappitelli M, Chanchlani R. J Am Soc Nephrol. 2021 Aug; 2021 May 26. PMID: 34039667.
- 24-hour ambulatory blood pressure monitoring 9 years after pediatric cardiac surgery: a pilot and feasibility study.Fredric D, Greenberg JH, Parikh CR, Devarajan P, Chui H, Cockovski V, Pizzi M, Palijan A, Hessey E, Jia Y, Thiessen-Philbrook HR, Zappitelli M. Pediatr Nephrol. 2021 Jun; 2021 Jan 7. PMID: 33411068.
- The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study.Moledina DG, Simonov M, Yamamoto Y, Alausa J, Arora T, Biswas A, Cantley LG, Ghazi L, Greenberg JH, Hinchcliff M, Huang C, Mansour SG, Martin M, Peixoto A, Schulz W, Subair L, Testani JM, Ugwuowo U, Young P, Wilson FP. Am J Kidney Dis. 2021 Apr; 2021 Jan 8. PMID: 33422598.
- Cardiac Biomarkers for Risk Stratification of Acute Kidney Injury After Pediatric Cardiac Surgery.Greenberg JH, Parsons M, Zappitelli M, Jia Y, Thiessen-Philbrook HR, Devarajan P, Everett AD, Parikh CR. Ann Thorac Surg. 2021 Jan; 2020 Apr 10. PMID: 32283087.
- Real-Time Prediction of Acute Kidney Injury in Hospitalized Adults: Implementation and Proof of Concept.Ugwuowo U, Yamamoto Y, Arora T, Saran I, Partridge C, Biswas A, Martin M, Moledina DG, Greenberg JH, Simonov M, Mansour SG, Vela R, Testani JM, Rao V, Rentfro K, Obeid W, Parikh CR, Wilson FP. Am J Kidney Dis. 2020 Dec; 2020 Jun 4. PMID: 32505812.
- Acute Kidney Injury and Risk of CKD and Hypertension after Pediatric Cardiac Surgery.Zappitelli M, Parikh CR, Kaufman JS, Go AS, Kimmel PL, Hsu CY, Coca SG, Chinchilli VM, Greenberg JH, Moxey-Mims MM, Ikizler TA, Cockovski V, Dyer AM, Devarajan P. Clin J Am Soc Nephrol. 2020 Oct 7; 2020 Sep 18. PMID: 32948644.
- A Time-Updated, Parsimonious Model to Predict AKI in Hospitalized Children.Sandokji I, Yamamoto Y, Biswas A, Arora T, Ugwuowo U, Simonov M, Saran I, Martin M, Testani JM, Mansour S, Moledina DG, Greenberg JH, Wilson FP. J Am Soc Nephrol. 2020 Jun; 2020 May 7. PMID: 32381598.
- Novel biomarkers of acute kidney injury in children: an update on recent findings.Sandokji I, Greenberg JH. Curr Opin Pediatr. 2020 Jun. PMID: 32332324.
- Plasma Biomarkers of Tubular Injury and Inflammation Are Associated with CKD Progression in Children.Greenberg JH, Abraham AG, Xu Y, Schelling JR, Feldman HI, Sabbisetti VS, Gonzalez MC, Coca S, Schrauben SJ, Waikar SS, Ramachandran VS, Shlipak MG, Warady B, Kimmel PL, Bonventre JV, Denburg M, Parikh CR, Furth S. J Am Soc Nephrol. 2020 May; 2020 Mar 31. PMID: 32234829.
- Secular Trends in Incidence, Modality and Mortality with Dialysis Receiving AKI in Children in Ontario: A Population-Based Cohort Study.Chanchlani R, Nash DM, McArthur E, Zappitelli M, Archer V, Kuwornu JP, Garg AX, Greenberg JH, Goldstein SL, Thabane L, Wald R. Clin J Am Soc Nephrol. 2019 Sep 6; 2019 Aug 23. PMID: 31444174.
- The Association Between Cardiac Biomarker NT-proBNP and 30-Day Readmission or Mortality After Pediatric Congenital Heart Surgery.Parker DM, Everett AD, Stabler ME, Leyenaar J, Vricella L, Jacobs JP, Thiessen-Philbrook H, Parikh C, Greenberg JH, Brown JR. World J Pediatr Congenit Heart Surg. 2019 Jul. PMID: 31307305.
- Kidney injury biomarkers 5 years after AKI due to pediatric cardiac surgery.Greenberg JH, Devarajan P, Thiessen-Philbrook HR, Krawczeski C, Parikh CR, Zappitelli M. Pediatr Nephrol. 2018 Jun; 2018 Mar 6. PMID: 29511889.
- Biomarkers of AKI Progression after Pediatric Cardiac Surgery.Greenberg JH, Zappitelli M, Jia Y, Thiessen-Philbrook HR, de Fontnouvelle CA, Wilson FP, Coca S, Devarajan P, Parikh CR. J Am Soc Nephrol. 2018 May; 2018 Feb 22. PMID: 29472416.
- Acute Kidney Injury in Real Time: Prediction, Alerts, and Clinical Decision Support.Wilson FP, Greenberg JH. Nephron. 2018; 2018 Aug 2. PMID: 30071528.
- Interleukin-8 and Tumor Necrosis Factor Predict Acute Kidney Injury After Pediatric Cardiac Surgery.de Fontnouvelle CA, Greenberg JH, Thiessen-Philbrook HR, Zappitelli M, Roth J, Kerr KF, Devarajan P, Shlipak M, Coca S, Parikh CR. Ann Thorac Surg. 2017 Dec; 2017 Aug 16. PMID: 28821332.
- Biomarkers for Diagnosis and Prognosis of AKI in Children: One Size Does Not Fit All.Greenberg JH, Parikh CR. Clin J Am Soc Nephrol. 2017 Sep 7; 2017 Jun 30. PMID: 28667085.
- Kidney Outcomes 5 Years After Pediatric Cardiac Surgery: The TRIBE-AKI Study.Greenberg JH, Zappitelli M, Devarajan P, Thiessen-Philbrook HR, Krawczeski C, Li S, Garg AX, Coca S, Parikh CR. JAMA Pediatr. 2016 Nov 1. PMID: 27618162.
- Interleukin-6 and interleukin-10 as acute kidney injury biomarkers in pediatric cardiac surgery.Greenberg JH, Whitlock R, Zhang WR, Thiessen-Philbrook HR, Zappitelli M, Devarajan P, Eikelboom J, Kavsak PA, Devereaux PJ, Shortt C, Garg AX, Parikh CR. Pediatr Nephrol. 2015 Sep; 2015 Apr 15. PMID: 25877915.
- Association of definition of acute kidney injury by cystatin C rise with biomarkers and clinical outcomes in children undergoing cardiac surgery.Zappitelli M, Greenberg JH, Coca SG, Krawczeski CD, Li S, Thiessen-Philbrook HR, Bennett MR, Devarajan P, Parikh CR. JAMA Pediatr. 2015 Jun. PMID: 25844892.
- Long-term risk of chronic kidney disease and mortality in children after acute kidney injury: a systematic review.Greenberg JH, Coca S, Parikh CR. BMC Nephrol. 2014 Nov 21; 2014 Nov 21. PMID: 25416588.