William Hellenbrand, MD
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Cards
Appointments
Pediatric Cardiology
Primary
Contact Info
Pediatric Cardiology
PO Box 208064
New Haven, CT 06510-8064
United States
About
Titles
Professor Emeritus of Pediatrics (Cardiology)
Biography
Dr. Hellenbrand is a pediatric cardiologist who completed his internship, residency, and fellowship at the Yale University School of Medicine before starting as a faculty member at Yale, for which he served for 24 years. In 1999, he became the Director of the Cardiac Catheterization lab at Columbia University Medical Center, before assuming the role of Director of the Division of Pediatric Cardiology at Columbia. In September of 2011, he returned to his roots at Yale, where he served as Section Chief for Pediatric Cardiology at Yale University School of Medicine.
Dr. Hellenbrand has an international reputation as a leader in the field of pediatric and adult congenital cardiac catheterization. He was instrumental in the development of transcatheter devices to close congenital heart defects including ASDs and PDAs. Most recently, he was one of the principal investigators in the U.S. trials of the trans-catheter implanted Melody valves. He remains very active in the field of congenital heart catheterization, performing procedures, teaching others, and lecturing regularly.
Appointments
Pediatric Cardiology
EmeritusPrimary
Other Departments & Organizations
- Adult Congenital Heart Program
- Children’s Heart Center
- Pediatric Cardiology
- Pediatric Interventional Cardiac Catheterization Program
- Pediatrics
- Yale Ventures
Education & Training
- Fellowship
- Yale University School of Medicine (1976)
- Fellowship
- Yale University School of Medicine (1973)
- Residency
- Yale-New Haven Hospital (1972)
- MD
- SUNY Downstate Medical Center (1970)
Board Certifications
Pediatric Cardiology
- Certification Organization
- AB of Pediatrics
- Original Certification Date
- 1977
Pediatrics
- Certification Organization
- AB of Pediatrics
- Original Certification Date
- 1975
Research
Research at a Glance
Publications Timeline
A big-picture view of William Hellenbrand's research output by year.
7Publications
1,118Citations
Publications
2012
Melody Valve Implant Within Failed Bioprosthetic Valves in the Pulmonary Position
Gillespie MJ, Rome JJ, Levi DS, Williams RJ, Rhodes JF, Cheatham JP, Hellenbrand WE, Jones TK, Vincent JA, Zahn EM, McElhinney DB. Melody Valve Implant Within Failed Bioprosthetic Valves in the Pulmonary Position. Circulation Cardiovascular Interventions 2012, 5: 862-870. PMID: 23212395, DOI: 10.1161/circinterventions.112.972216.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdolescentAdultArterial PressureBioprosthesisCardiac CatheterizationChildChild, PreschoolEndocarditisFemaleHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHumansKaplan-Meier EstimateMaleMiddle AgedProsthesis DesignProsthesis FailurePulmonary ArteryPulmonary ValvePulmonary Valve InsufficiencyRetrospective StudiesTime FactorsTreatment OutcomeUnited StatesVentricular Function, RightVentricular PressureYoung AdultConceptsTranscatheter pulmonary valve implantationPulmonary valve implantationMelody valveValve implantationBioprosthetic valvesPulmonary positionRight ventricular outflow tract dysfunctionRight ventricular outflow tract gradientLow procedure-related morbidityRight ventricular systolic pressureVentricular outflow tract gradientExcellent short-term resultsMelody valve implantationPreliminary multicenter experiencePulmonary artery gradientTranscatheter treatment optionsOutflow tract gradientOff-label indicationsVentricular systolic pressureProcedure-related morbidityCases of endocarditisShort-term resultsBPV procedureTract gradientTract dysfunctionReliability and Accuracy of Echocardiographic Right Heart Evaluation in the U.S. Melody Valve Investigational Trial
Brown DW, McElhinney DB, Araoz PA, Zahn EM, Vincent JA, Cheatham JP, Jones TK, Hellenbrand WE, O’Leary P. Reliability and Accuracy of Echocardiographic Right Heart Evaluation in the U.S. Melody Valve Investigational Trial. Journal Of The American Society Of Echocardiography 2012, 25: 383-392.e4. PMID: 22265459, DOI: 10.1016/j.echo.2011.12.022.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAdolescentAdultCardiac CatheterizationChildEchocardiography, DopplerHeart Valve Prosthesis ImplantationHeart VentriclesHemodynamicsHumansMagnetic Resonance ImagingMalePatient SelectionPulmonary ValveReproducibility of ResultsTherapies, InvestigationalVentricular Function, RightVentricular Outflow ObstructionVentricular PressureYoung AdultConceptsRV end-diastolic volumeCardiac magnetic resonanceEnd-diastolic volumePulmonary regurgitationRV functionEchocardiographic assessmentDiastolic areaTranscatheter pulmonary valve replacementPR fractionRight heart evaluationPulmonary valve replacementDoppler echocardiographic assessmentRight ventricular performanceAppropriate patient selectionRV ejection fractionAccuracy of echocardiographyCMR RV ejection fractionSuitable screening testExcellent interobserver agreementGood categorical agreementTract obstructionDoppler gradientValve replacementRV sizeEjection fraction
2011
Short-Term Performance of the Transcatheter Melody Valve in High-Pressure Hemodynamic Environments in the Pulmonary and Systemic Circulations
Hasan BS, McElhinney DB, Brown DW, Cheatham JP, Vincent JA, Hellenbrand WE, Jones TK, Zahn EM, Lock JE. Short-Term Performance of the Transcatheter Melody Valve in High-Pressure Hemodynamic Environments in the Pulmonary and Systemic Circulations. Circulation Cardiovascular Interventions 2011, 4: 615-620. PMID: 22075926, DOI: 10.1161/circinterventions.111.963389.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdolescentAgedAortic ValveBlood CirculationCardiac CatheterizationChild, PreschoolFollow-Up StudiesHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHemodynamicsHumansInfantMitral ValvePulmonary CirculationPulmonary ValveRegional Blood FlowRetrospective StudiesTime FactorsTreatment OutcomeUnited StatesVentricular Dysfunction, RightYoung AdultConceptsMelody valveDysfunctional right ventricular outflow tractsUS Investigational Device Exemption TrialInvestigational device exemption trialPercutaneous pulmonary valve replacementRight ventricular outflow tractProcedure-related deathsPulmonary valve replacementGood valve functionVentricular outflow tractShort-term resultsValve replacementSevere regurgitationMild regurgitationPulmonary circulationSevere stenosisOutflow tractInclusion criteriaCatheterization laboratorySystemic circulationValve functionAortic implantsRegurgitationPatientsImplantsStent Fracture, Valve Dysfunction, and Right Ventricular Outflow Tract Reintervention After Transcatheter Pulmonary Valve Implantation
McElhinney DB, Cheatham JP, Jones TK, Lock JE, Vincent JA, Zahn EM, Hellenbrand WE. Stent Fracture, Valve Dysfunction, and Right Ventricular Outflow Tract Reintervention After Transcatheter Pulmonary Valve Implantation. Circulation Cardiovascular Interventions 2011, 4: 602-614. PMID: 22075927, DOI: 10.1161/circinterventions.111.965616.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdolescentAdultCardiac CatheterizationChildEquipment FailureHeart Valve DiseasesHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHeart VentriclesHumansKaplan-Meier EstimateMiddle AgedMultivariate AnalysisPulmonary ValveRetrospective StudiesRisk FactorsStentsTetralogy of FallotTransposition of Great VesselsUnited StatesVentricular Outflow ObstructionYoung AdultConceptsVentricular outflow tract reinterventionAnterior chest wallRVOT reinterventionStent fractureBioprosthetic valvesChest wallRight ventricular outflow tract reinterventionTranscatheter pulmonary valve implantationTranscatheter pulmonary valve replacementInvestigational device exemption trialPulmonary valve replacementPulmonary valve implantationRVOT conduitTPV implantationMelody valveMulticenter experienceValve dysfunctionValve replacementLonger freedomValve implantationMultivariable analysisShorter freedomPrior catheterizationRisk factorsReinterventionCatheterization for Congenital Heart Disease Adjustment for Risk Method (CHARM)
Bergersen L, Gauvreau K, Foerster SR, Marshall AC, McElhinney DB, Beekman RH, Hirsch R, Kreutzer J, Balzer D, Vincent J, Hellenbrand WE, Holzer R, Cheatham JP, Moore JW, Burch G, Armsby L, Lock JE, Jenkins KJ. Catheterization for Congenital Heart Disease Adjustment for Risk Method (CHARM). JACC Cardiovascular Interventions 2011, 4: 1037-1046. PMID: 21939947, DOI: 10.1016/j.jcin.2011.05.021.Peer-Reviewed Original ResearchCitations
2009
Adverse event rates in congenital cardiac catheterization — A multi‐center experience
Bergersen L, Marshall A, Gauvreau K, Beekman R, Hirsch R, Foerster S, Balzer D, Vincent J, Hellenbrand W, Holzer R, Cheatham J, Moore J, Lock J, Jenkins K. Adverse event rates in congenital cardiac catheterization — A multi‐center experience. Catheterization And Cardiovascular Interventions 2009, 75: 389-400. PMID: 19885913, DOI: 10.1002/ccd.22266.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsAdverse event ratesIncidence of AEsAdverse eventsCardiac catheterizationCongenital cardiac catheterizationEvent ratesBiopsy casesHigh-severity adverse eventsMedian rateDiagnostic casesMulti-institutional cohortMulti-center experienceCongenital heart diseaseCase-mix variationVariable case mixRisk adjustment methodsGeneral anesthesiaPediatric institutionHeart diseaseMedian numberInterventional casesCatheterizationCase mixOutcomes ProjectCompleteness of dataImplantation of the Melody Transcatheter Pulmonary Valve in Patients With a Dysfunctional Right Ventricular Outflow Tract Conduit Early Results From the U.S. Clinical Trial
Zahn EM, Hellenbrand WE, Lock JE, McElhinney DB. Implantation of the Melody Transcatheter Pulmonary Valve in Patients With a Dysfunctional Right Ventricular Outflow Tract Conduit Early Results From the U.S. Clinical Trial. Journal Of The American College Of Cardiology 2009, 54: 1722-1729. PMID: 19850214, DOI: 10.1016/j.jacc.2009.06.034.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsCardiac CatheterizationEchocardiographyEchocardiography, DopplerExercise TestFemaleFollow-Up StudiesHeart Valve ProsthesisHumansMagnetic Resonance ImagingMaleProspective StudiesProsthesis DesignPulmonary ValveTomography, X-Ray ComputedTreatment OutcomeVentricular Dysfunction, RightVentricular Outflow ObstructionYoung AdultConceptsMelody transcatheter pulmonary valveDoppler mean gradientTranscatheter pulmonary valvePulmonary regurgitationConduit dysfunctionPulmonary valveDysfunctional right ventricular outflow tract conduitsRight ventricular outflow tract conduit dysfunctionRight ventricular outflow tract conduitsTranscatheter pulmonary valve placementMelody valve implantationMild pulmonary regurgitationMean gradientSevere pulmonary regurgitationShort-term outcomesU.S. clinical trialsWide complex tachycardiaShort-term effectivenessMagnetic resonance imagingConduit ruptureMelody valveUrgent surgeryRecurrent stenosisValve implantationDevice explant
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News
- May 22, 2023
Outliving disease
- October 01, 2011
Cardiologist returns to Yale as new section chief
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Pediatric Cardiology
PO Box 208064
New Haven, CT 06510-8064
United States