Novak Yang, PhD
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About
Departments & Organizations
Education & Training
- PhD
- Yale University, Immunology (2025)
- MS
- Emory University, Cancer Biology and Translational Oncology (2019)
- BS
- Emory University, Biology (2018)
- AA
- Emory University, Liberal Arts and Sciences (2016)
Research
Overview
Medical Research Interests
Drug Development; Drug Discovery; Drug Screening Assays, Antitumor; High-Throughput Screening Assays; Immunotherapy; Therapeutics; Tumor Microenvironment
ORCID
0000-0002-7799-7705
Research at a Glance
Yale Co-Authors
Frequent collaborators of Novak Yang's published research.
Publications Timeline
A big-picture view of Novak Yang's research output by year.
Research Interests
Research topics Novak Yang is interested in exploring.
Dejian Zhao, PhD
Jacky Yeung, MD, FAANS
Kurt Schalper, MD, PhD
Lieping Chen, MD, PhD
Matthew Vesely, MD, PhD
Miguel Sanmamed, MD, PhD
7Publications
8Citations
Immunotherapy
Publications
2024
Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity
Zhang T, Yu W, Cheng X, Yeung J, Ahumada V, Norris P, Pearson M, Yang X, van Deursen W, Halcovich C, Nassar A, Vesely M, Zhang Y, Zhang J, Ji L, Flies D, Liu L, Langermann S, LaRochelle W, Humphrey R, Zhao D, Zhang Q, Zhang J, Gu R, Schalper K, Sanmamed M, Chen L. Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity. Science Immunology 2024, 9: eadh2334. PMID: 38669316, DOI: 10.1126/sciimmunol.adh2334.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsT cell infiltrationT cell exclusionT cellsResistance to anti-PD-1 immunotherapyPoor T-cell infiltrationAnti-PD-1 immunotherapyImmunogenic mouse tumorsT cell mobilizationHuman cancer tissuesTherapeutic immunotherapyCancer immunotherapyMouse tumorsChemokine systemImmunotherapyTumor tissuesImpaired infiltrationTumorLipid metabolitesHuman cancersCancer tissuesInfiltrationA2 groupCancerPLA2G10Up-regulated
2022
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Mo X, Niu Q, Ivanov AA, Tsang YH, Tang C, Shu C, Li Q, Qian K, Wahafu A, Doyle SP, Cicka D, Yang X, Fan D, Reyna MA, Cooper LAD, Moreno CS, Zhou W, Owonikoko TK, Lonial S, Khuri FR, Du Y, Ramalingam SS, Mills GB, Fu H. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. Cell 2022, 185: 1974-1985.e12. PMID: 35512704, DOI: 10.1016/j.cell.2022.04.014.Peer-Reviewed Original Research
2021
Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer.
Yang X, Fan D, Troha AH, Ahn HM, Qian K, Liang B, Du Y, Fu H, Ivanov AA. Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer. Bioorganic & Medicinal Chemistry 2021, 45: 116324. PMID: 34333394, PMCID: PMC8456368, DOI: 10.1016/j.bmc.2021.116324.Peer-Reviewed Original ResearchHypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling.
Tang C, Mo X, Niu Q, Wahafu A, Yang X, Qui M, Ivanov AA, Du Y, Fu H. Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling. Cell Chemical Biology 2021, 28: 636-647.e5. PMID: 33326750, DOI: 10.1016/j.chembiol.2020.11.010.Peer-Reviewed Original Research
2020
High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients.
Yang X, Amgad M, Cooper LAD, Du Y, Fu H, Ivanov AA. High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients. Journal Of Translational Medicine 2020, 18: 334. PMID: 32873298, PMCID: PMC7465409, DOI: 10.1186/s12967-020-02502-w.Peer-Reviewed Original ResearchOnline informatics resources to facilitate cancer target and chemical probe discovery.
Yang X, Fu H, Ivanov AA. Online informatics resources to facilitate cancer target and chemical probe discovery. RSC Medicinal Chemistry 2020, 11: 611-624. PMID: 33479663, PMCID: PMC7429978, DOI: 10.1039/d0md00012d.Peer-Reviewed Original ResearchComputational structural modeling to discover PPI modulators
Yang X, Ivanov AA. Computational structural modeling to discover PPI modulators. Protein-protein interaction regulators, 87-108, Roy, S. & Fu, H. (Eds.) Royal Society of Chemistry.Chapters
Academic Achievements & Community Involvement
Honors
honor NIH/NCI F99/K00 Award
08/21/2024National AwardNational Cancer InstituteDetailsUnited Stateshonor Prize Teaching Award
04/19/2024Yale University AwardYale UniversityDetailsUnited Stateshonor Gruber Science Fellowship
08/30/2021Yale University AwardYale UniversityDetailsUnited Stateshonor SLAS Tony B. Academic Travel Award
01/25/2020National AwardSociety for Laboratory Automation and ScreeningDetailsUnited Stateshonor ASPET Travel Award
04/06/2019National AwardAmerican Society for Pharmacology and Experimental TherapeuticsDetailsUnited States