Nathaniel Bachtel
About
Research
Publications
Featured Publications
Immune sensing of food allergens promotes avoidance behaviour
Florsheim E, Bachtel N, Cullen J, Lima B, Godazgar M, Carvalho F, Chatain C, Zimmer M, Zhang C, Gautier G, Launay P, Wang A, Dietrich M, Medzhitov R. Immune sensing of food allergens promotes avoidance behaviour. Nature 2023, 620: 643-650. PMID: 37437602, PMCID: PMC10432274, DOI: 10.1038/s41586-023-06362-4.Peer-Reviewed Original ResearchAdverse Food Reactions: Physiological and Ecological Perspectives
Korn L, Kutyavin V, Bachtel N, Medzhitov R. Adverse Food Reactions: Physiological and Ecological Perspectives. Annual Review Of Nutrition 2024, 44: 155-178. PMID: 38724028, PMCID: PMC12372117, DOI: 10.1146/annurev-nutr-061021-022909.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsIntestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens
Bachtel N, Cullen J, Liu M, Erickson S, Kutyavin V, El-Naccache D, Florsheim E, Lim J, Sullivan Z, Imaeda R, Hudak A, Zhang C, Medzhitov R. Intestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens. Science 2025, 389: eadp0246-eadp0246. PMID: 40773543, PMCID: PMC12513082, DOI: 10.1126/science.adp0246.Peer-Reviewed Original Research
2025
Gut-to-brain signaling restricts dietary protein intake during recovery from catabolic states
Jaschke N, Luchsinger J, Chen Z, Wulfmeyer V, de la Rosa X, Hahn O, Zhang C, Bachtel N, Cullen J, Rachner T, Medzhitov R, Rinschen M, Wu C, Wang A. Gut-to-brain signaling restricts dietary protein intake during recovery from catabolic states. Cell 2025, 188: 7481-7494.e16. PMID: 41192423, PMCID: PMC12766652, DOI: 10.1016/j.cell.2025.10.005.Peer-Reviewed Original ResearchThe five senses of immunity
Nixon D, Bachtel N, Hupert N, Eleftherianos I. The five senses of immunity. Trends In Immunology 2025, 46: 361-363. PMID: 40251093, PMCID: PMC12172028, DOI: 10.1016/j.it.2025.03.005.Peer-Reviewed Original Research
2024
A model of proximate protection against pathogenic infection through shared immunity
Nixon D, Kyza-Karavioti M, Mallick S, Daley L, Hupert N, Bachtel N, Eleftherianos I. A model of proximate protection against pathogenic infection through shared immunity. MBio 2024, 15: e03046-24. PMID: 39526781, PMCID: PMC11633142, DOI: 10.1128/mbio.03046-24.Peer-Reviewed Original Research
2019
Introduction
Bachtel N, Israni-Winger K. Introduction. Axon 2019, 93: 227-228. PMCID: PMC7309659, DOI: 10.30687/axon/2532-6848/2019/06/000.Commentaries, Editorials and LettersThe Psychiatric Risk Gene NT5C2 Regulates Adenosine Monophosphate-Activated Protein Kinase Signaling and Protein Translation in Human Neural Progenitor Cells
Duarte RRR, Bachtel ND, Côtel MC, Lee SH, Selvackadunco S, Watson IA, Hovsepian GA, Troakes C, Breen GD, Nixon DF, Murray RM, Bray NJ, Eleftherianos I, Vernon AC, Powell TR, Srivastava DP. The Psychiatric Risk Gene NT5C2 Regulates Adenosine Monophosphate-Activated Protein Kinase Signaling and Protein Translation in Human Neural Progenitor Cells. Biological Psychiatry 2019, 86: 120-130. PMID: 31097295, PMCID: PMC6614717, DOI: 10.1016/j.biopsych.2019.03.977.Peer-Reviewed Original Research
2018
Short Communication: Expression of Host Restriction Factors by Memory CD4+ T Cells Differs Between Healthy Donors and HIV-1-Infected Individuals with Effective Antiretroviral Therapy
Bachtel ND, Beckerle GA, Mota TM, de Mulder Rougvie M, Raposo RAS, Jones RB, Nixon DF, Apps R. Short Communication: Expression of Host Restriction Factors by Memory CD4+ T Cells Differs Between Healthy Donors and HIV-1-Infected Individuals with Effective Antiretroviral Therapy. AIDS Research And Human Retroviruses 2018, 35: 108-111. PMID: 30198299, PMCID: PMC6343196, DOI: 10.1089/aid.2018.0162.Peer-Reviewed Original ResearchPublisher Correction: Evidence that CD32a does not mark the HIV-1 latent reservoir
Osuna C, Lim S, Kublin J, Apps R, Chen E, Mota T, Huang S, Ren Y, Bachtel N, Tsibris A, Ackerman M, Jones R, Nixon D, Whitney J. Publisher Correction: Evidence that CD32a does not mark the HIV-1 latent reservoir. Nature 2018, 563: e33-e33. PMID: 30315222, DOI: 10.1038/s41586-018-0611-3.Commentaries, Editorials and Letters