2019
Transient receptor potential melastatin 2 governs stress-induced depressive-like behaviors
Ko SY, Wang SE, Lee HK, Jo S, Han J, Lee SH, Choi M, Jo HR, Seo JY, Jung SJ, Son H. Transient receptor potential melastatin 2 governs stress-induced depressive-like behaviors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 1770-1775. PMID: 30642955, PMCID: PMC6358711, DOI: 10.1073/pnas.1814335116.Peer-Reviewed Original ResearchConceptsMajor depressive disorderChronic unpredictable stressReactive oxygen speciesStress-induced depressive-like behaviorTransient receptor potential melastatin 2Antidepressant-like behaviorDepressive-like behaviorStress-induced depressionEnvironmental risk factorsHippocampal tissue samplesHistone deacetylase 5Risk factorsDepressive disorderUnpredictable stressPermeable cation channelSynapsin 1Animal modelsType 2Calpain activationSynaptic functionChronic stressMRNA expressionCation channelsTissue samplesPossible targets
2018
Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice
Wang SE, Ko SY, Kim YS, Jo S, Lee SH, Jung SJ, Son H. Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice. Experimental & Molecular Medicine 2018, 50: e455-e455. PMID: 29520110, PMCID: PMC5898893, DOI: 10.1038/emm.2017.289.Peer-Reviewed Original ResearchConceptsTransient receptor potential vanilloid 1Histone deacetylase 2Synapsin IAgonist of TRPV1Synaptic plasticityRole of HDAC2GluR2 promoterCapsaicin treatmentVanilloid 1Neuronal maturationMouse hippocampusTRPV1 activityHippocampal knockdownChromatin remodelingTranscriptional regulationSynaptic moleculesCapsaicinMolecular linkGene expressionMicePresent studyDetrimental effectsRegulationSynaptophysinHippocampus
2017
Oleanolic Acid Promotes Neuronal Differentiation and Histone Deacetylase 5 Phosphorylation in Rat Hippocampal Neurons
Jo HR, Wang SE, Kim YS, Lee CH, Son H. Oleanolic Acid Promotes Neuronal Differentiation and Histone Deacetylase 5 Phosphorylation in Rat Hippocampal Neurons. Molecules And Cells 2017, 40: 485-494. PMID: 28681592, PMCID: PMC5547218, DOI: 10.14348/molcells.2017.0034.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAnimalsCell DifferentiationCell NucleusDendritic SpinesGene Expression RegulationHippocampusHistone DeacetylasesMEF2 Transcription FactorsNeural Stem CellsNeuritesNeuronsOleanolic AcidPhosphorylationProtein Kinase CRats, Sprague-DawleySubcellular FractionsSynapsesConceptsRat hippocampal neural progenitor cellsEffects of OAHippocampal neural progenitor cellsNeuronal differentiationOA derivativesOleanolic acidHDAC5 phosphorylationHistone deacetylase 5 (HDAC5) phosphorylationRat hippocampal neuronsNeural progenitor cellsPromotes Neuronal DifferentiationHistone deacetylase 5Neurotrophic effectsHippocampal neuronsNeurological drugsProgenitor cellsNeural differentiationNeuronsPresent studyTarget genesExpressionFurther researchGene expressionPhosphorylationDifferentiationTRPV1 Regulates Stress Responses through HDAC2
Wang SE, Ko SY, Jo S, Choi M, Lee SH, Jo HR, Seo JY, Lee SH, Kim YS, Jung SJ, Son H. TRPV1 Regulates Stress Responses through HDAC2. Cell Reports 2017, 19: 401-412. PMID: 28402861, DOI: 10.1016/j.celrep.2017.03.050.Peer-Reviewed Original ResearchConceptsTransient receptor potential vanilloid 1Neuroplasticity-related moleculesTRPV1-deficient miceChronic unpredictable stressNon-selective cation channelsStress-induced behaviorsHDAC2 overexpressionVanilloid 1Control micePain sensationUnpredictable stressTRPV1 activityHippocampal knockdownNeurotransmission systemsGlucocorticoid receptorBehavioral effectsCation channelsMiceStress responseHDAC2BrainSimilar effectsMolecular linkCellular levelResponse
2015
Ketamine produces antidepressant-like effects through phosphorylation-dependent nuclear export of histone deacetylase 5 (HDAC5) in rats
Choi M, Lee SH, Wang SE, Ko SY, Song M, Choi JS, Kim YS, Duman RS, Son H. Ketamine produces antidepressant-like effects through phosphorylation-dependent nuclear export of histone deacetylase 5 (HDAC5) in rats. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 15755-15760. PMID: 26647181, PMCID: PMC4697416, DOI: 10.1073/pnas.1513913112.Peer-Reviewed Original ResearchConceptsHistone deacetylase 5Myocyte enhancer factor 2MEF2 target genesNuclear exportTarget genesTranscriptional activityPhosphorylation-dependent nuclear exportPhosphorylation-defective mutantProtein kinase DHistone deacetylase 5 (HDAC5) phosphorylationMEF2 transcriptional activityAntidepressant-like effectsCalcium/calmodulin kinase IICalmodulin kinase IIKinase DKinase IIMolecular mechanismsNovel roleRapid antidepressant-like effectsDependent pathwayAction of ketamineFactor 2Rat hippocampal neuronsGenesHippocampal knockdown
2014
Overexpression of Human GATA-1 and GATA-2 Interferes with Spine Formation and Produces Depressive Behavior in Rats
Choi M, Wang SE, Ko SY, Kang HJ, Chae SY, Lee SH, Kim YS, Duman RS, Son H. Overexpression of Human GATA-1 and GATA-2 Interferes with Spine Formation and Produces Depressive Behavior in Rats. PLOS ONE 2014, 9: e109253. PMID: 25340772, PMCID: PMC4207676, DOI: 10.1371/journal.pone.0109253.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalCells, CulturedDendritic SpinesDependovirusDepressionGATA1 Transcription FactorGATA2 Transcription FactorGene Expression RegulationGreen Fluorescent ProteinsHippocampusHumansMaleRats, Sprague-DawleyRats, TransgenicRNA, Small InterferingSynapsesTranscription, GeneticConceptsSynapse-related genesSpine numberDentate gyrusDepressive behaviorDorsal hippocampusHippocampal neuronsSpine formationViral expressionDepressive-like deficitsSpine synapse densitySynapse-related gene expressionEffects of adenoRat hippocampal neuronsViral-mediated expressionModel of depressionSwim testSynapse densityDendritic outgrowthAdult brainHippocampusNeuronal differentiationDendrite branchingShRNA knockdownGATA-2Helplessness model