Abnormal kynurenine level contributes to the pathological bone features of ankylosing spondylitis
Jeon C, Jang Y, Lee S, Weon S, Park H, Lee S, Oh Y, Choi S, Wang S, Kim T, Sung I, Jo S. Abnormal kynurenine level contributes to the pathological bone features of ankylosing spondylitis. International Immunopharmacology 2023, 118: 110132. PMID: 37023698, DOI: 10.1016/j.intimp.2023.110132.Peer-Reviewed Original ResearchConceptsModified Stoke Ankylosing Spondylitis Spinal ScoreKyn levelsMouse osteoclast precursorsSera levelsAnkylosing spondylitisStoke Ankylosing Spondylitis Spinal ScoreAS groupDisease activity of ASKyn treatmentOsteoclast formationOsteoclast precursorsTRAP-positive osteoclast formationOsteoblast differentiationSystemic bone lossRANKL-mediated osteoclast differentiationBone formationBone mineralizationCell proliferationFeatures of ankylosing spondylitisOsteoclast differentiation markersRANKL-mediated osteoclastogenesisMRNA expression markersActivity of ASAlkaline phosphateKynurenine levels