2019
Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2
Wang S, Ko S, Jo S, Jo H, Han J, Kim Y, Son H. Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2. Experimental Neurobiology 2019, 28: 537-546. PMID: 31495082, PMCID: PMC6751865, DOI: 10.5607/en.2019.28.4.537.Peer-Reviewed Original ResearchPlasticity-related genesSynaptic plasticity-related genesLysine N-methyltransferase 2Cellular oxidative stress responseDepression-like behaviorSilent information regulator 2Oxidative stress responseDownregulation of SIRT2SIRT2 expressionTranscriptional silencingKnockdown of SIRT2Protein stabilityRegulator 2Target proteinsChronic stressStress responseHippocampus-dependent cognitive functionDependent deacetylaseGenesBiochemical analysisStress-induced decreaseSIRT2Reduces ExpressionExpressionMood disorders
2017
TRPV1 Regulates Stress Responses through HDAC2
Wang SE, Ko SY, Jo S, Choi M, Lee SH, Jo HR, Seo JY, Lee SH, Kim YS, Jung SJ, Son H. TRPV1 Regulates Stress Responses through HDAC2. Cell Reports 2017, 19: 401-412. PMID: 28402861, DOI: 10.1016/j.celrep.2017.03.050.Peer-Reviewed Original ResearchConceptsTransient receptor potential vanilloid 1Neuroplasticity-related moleculesTRPV1-deficient miceChronic unpredictable stressNon-selective cation channelsStress-induced behaviorsHDAC2 overexpressionVanilloid 1Control micePain sensationUnpredictable stressTRPV1 activityHippocampal knockdownNeurotransmission systemsGlucocorticoid receptorBehavioral effectsCation channelsMiceStress responseHDAC2BrainSimilar effectsMolecular linkCellular levelResponse