2022
Epigenetic Epidemiology of Autism and Other Neurodevelopmental Disorders
Wang S, Jiang Y. Epigenetic Epidemiology of Autism and Other Neurodevelopmental Disorders. 2022, 405-426. DOI: 10.1007/978-3-030-94475-9_17.ChaptersEpigenome-wide association studiesAbnormal DNA methylationDNA methylationHistone modificationsTissue-specific patternsNeurodevelopmental disordersEpigenetic regulationEpigenetic epidemiologyEmbryonic developmentEpigenetic dysregulationGenetic lociEpigenetic reprogramingAssociation studiesMethylationRecent technical advancesEnvironmental factorsRegion analysisEpimutationsReprogramingEtiology of NDDIntellectual disabilityLociTechnical advancesAllelesRegulation
2018
Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice
Wang SE, Ko SY, Kim YS, Jo S, Lee SH, Jung SJ, Son H. Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice. Experimental & Molecular Medicine 2018, 50: e455-e455. PMID: 29520110, PMCID: PMC5898893, DOI: 10.1038/emm.2017.289.Peer-Reviewed Original ResearchConceptsTransient receptor potential vanilloid 1Histone deacetylase 2Synapsin IAgonist of TRPV1Synaptic plasticityRole of HDAC2GluR2 promoterCapsaicin treatmentVanilloid 1Neuronal maturationMouse hippocampusTRPV1 activityHippocampal knockdownChromatin remodelingTranscriptional regulationSynaptic moleculesCapsaicinMolecular linkGene expressionMicePresent studyDetrimental effectsRegulationSynaptophysinHippocampus