2021
LGI1 governs neuritin-mediated resilience to chronic stress
Lee S, Kim N, Choi M, Ko S, Wang S, Jo H, Seo J, Kim Y, Kim H, Lee H, Kim J, Son H. LGI1 governs neuritin-mediated resilience to chronic stress. Neurobiology Of Stress 2021, 15: 100373. PMID: 34401409, PMCID: PMC8350063, DOI: 10.1016/j.ynstr.2021.100373.Peer-Reviewed Original ResearchLeucine-rich glioma-inactivated protein 1Chronic unpredictable stressLGI1 expressionAntidepressant-like behaviorHippocampus of miceHistone deacetylase 5 (HDAC5) phosphorylationDevelopment of CNSInsulin receptor inhibitorNeuronal atrophyFlox/Unpredictable stressReceptor inhibitorsChronic stressNeuritinHDAC5 phosphorylationProtein 1Pathological depressionMetastasis suppressorEndogenous proteinsNeurite outgrowthMiceDepressionStress resilienceCritical roleExpression
2018
Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice
Wang SE, Ko SY, Kim YS, Jo S, Lee SH, Jung SJ, Son H. Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice. Experimental & Molecular Medicine 2018, 50: e455-e455. PMID: 29520110, PMCID: PMC5898893, DOI: 10.1038/emm.2017.289.Peer-Reviewed Original ResearchConceptsTransient receptor potential vanilloid 1Histone deacetylase 2Synapsin IAgonist of TRPV1Synaptic plasticityRole of HDAC2GluR2 promoterCapsaicin treatmentVanilloid 1Neuronal maturationMouse hippocampusTRPV1 activityHippocampal knockdownChromatin remodelingTranscriptional regulationSynaptic moleculesCapsaicinMolecular linkGene expressionMicePresent studyDetrimental effectsRegulationSynaptophysinHippocampus
2017
TRPV1 Regulates Stress Responses through HDAC2
Wang SE, Ko SY, Jo S, Choi M, Lee SH, Jo HR, Seo JY, Lee SH, Kim YS, Jung SJ, Son H. TRPV1 Regulates Stress Responses through HDAC2. Cell Reports 2017, 19: 401-412. PMID: 28402861, DOI: 10.1016/j.celrep.2017.03.050.Peer-Reviewed Original ResearchConceptsTransient receptor potential vanilloid 1Neuroplasticity-related moleculesTRPV1-deficient miceChronic unpredictable stressNon-selective cation channelsStress-induced behaviorsHDAC2 overexpressionVanilloid 1Control micePain sensationUnpredictable stressTRPV1 activityHippocampal knockdownNeurotransmission systemsGlucocorticoid receptorBehavioral effectsCation channelsMiceStress responseHDAC2BrainSimilar effectsMolecular linkCellular levelResponse