Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2
Wang S, Ko S, Jo S, Jo H, Han J, Kim Y, Son H. Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2. Experimental Neurobiology 2019, 28: 537-546. PMID: 31495082, PMCID: PMC6751865, DOI: 10.5607/en.2019.28.4.537.Peer-Reviewed Original ResearchPlasticity-related genesSynaptic plasticity-related genesLysine N-methyltransferase 2Cellular oxidative stress responseDepression-like behaviorSilent information regulator 2Oxidative stress responseDownregulation of SIRT2SIRT2 expressionTranscriptional silencingKnockdown of SIRT2Protein stabilityRegulator 2Target proteinsChronic stressStress responseHippocampus-dependent cognitive functionDependent deacetylaseGenesBiochemical analysisStress-induced decreaseSIRT2Reduces ExpressionExpressionMood disorders