2019
Transient receptor potential melastatin 2 governs stress-induced depressive-like behaviors
Ko SY, Wang SE, Lee HK, Jo S, Han J, Lee SH, Choi M, Jo HR, Seo JY, Jung SJ, Son H. Transient receptor potential melastatin 2 governs stress-induced depressive-like behaviors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 1770-1775. PMID: 30642955, PMCID: PMC6358711, DOI: 10.1073/pnas.1814335116.Peer-Reviewed Original ResearchConceptsMajor depressive disorderChronic unpredictable stressReactive oxygen speciesStress-induced depressive-like behaviorTransient receptor potential melastatin 2Antidepressant-like behaviorDepressive-like behaviorStress-induced depressionEnvironmental risk factorsHippocampal tissue samplesHistone deacetylase 5Risk factorsDepressive disorderUnpredictable stressPermeable cation channelSynapsin 1Animal modelsType 2Calpain activationSynaptic functionChronic stressMRNA expressionCation channelsTissue samplesPossible targets
2017
TRPV1 Regulates Stress Responses through HDAC2
Wang SE, Ko SY, Jo S, Choi M, Lee SH, Jo HR, Seo JY, Lee SH, Kim YS, Jung SJ, Son H. TRPV1 Regulates Stress Responses through HDAC2. Cell Reports 2017, 19: 401-412. PMID: 28402861, DOI: 10.1016/j.celrep.2017.03.050.Peer-Reviewed Original ResearchConceptsTransient receptor potential vanilloid 1Neuroplasticity-related moleculesTRPV1-deficient miceChronic unpredictable stressNon-selective cation channelsStress-induced behaviorsHDAC2 overexpressionVanilloid 1Control micePain sensationUnpredictable stressTRPV1 activityHippocampal knockdownNeurotransmission systemsGlucocorticoid receptorBehavioral effectsCation channelsMiceStress responseHDAC2BrainSimilar effectsMolecular linkCellular levelResponse