2021
LGI1 governs neuritin-mediated resilience to chronic stress
Lee S, Kim N, Choi M, Ko S, Wang S, Jo H, Seo J, Kim Y, Kim H, Lee H, Kim J, Son H. LGI1 governs neuritin-mediated resilience to chronic stress. Neurobiology Of Stress 2021, 15: 100373. PMID: 34401409, PMCID: PMC8350063, DOI: 10.1016/j.ynstr.2021.100373.Peer-Reviewed Original ResearchLeucine-rich glioma-inactivated protein 1Chronic unpredictable stressLGI1 expressionAntidepressant-like behaviorHippocampus of miceHistone deacetylase 5 (HDAC5) phosphorylationDevelopment of CNSInsulin receptor inhibitorNeuronal atrophyFlox/Unpredictable stressReceptor inhibitorsChronic stressNeuritinHDAC5 phosphorylationProtein 1Pathological depressionMetastasis suppressorEndogenous proteinsNeurite outgrowthMiceDepressionStress resilienceCritical roleExpression
2019
Transient receptor potential melastatin 2 governs stress-induced depressive-like behaviors
Ko SY, Wang SE, Lee HK, Jo S, Han J, Lee SH, Choi M, Jo HR, Seo JY, Jung SJ, Son H. Transient receptor potential melastatin 2 governs stress-induced depressive-like behaviors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 1770-1775. PMID: 30642955, PMCID: PMC6358711, DOI: 10.1073/pnas.1814335116.Peer-Reviewed Original ResearchConceptsMajor depressive disorderChronic unpredictable stressReactive oxygen speciesStress-induced depressive-like behaviorTransient receptor potential melastatin 2Antidepressant-like behaviorDepressive-like behaviorStress-induced depressionEnvironmental risk factorsHippocampal tissue samplesHistone deacetylase 5Risk factorsDepressive disorderUnpredictable stressPermeable cation channelSynapsin 1Animal modelsType 2Calpain activationSynaptic functionChronic stressMRNA expressionCation channelsTissue samplesPossible targets