2021
GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension
Drzewiecki K, Choi J, Brancale J, Leney-Greene MA, Sari S, Dalgiç B, Aksu A, Şahin G, Ozen A, Baris S, Karakoc-Aydiner E, Jain D, Kleiner D, Schmalz M, Radhakrishnan K, Zhang J, Hoebe K, Su HC, Pereira JP, Lenardo MJ, Lifton RP, Vilarinho S. GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension. Journal Of Experimental Medicine 2021, 218: e20201745. PMID: 33956074, PMCID: PMC8105721, DOI: 10.1084/jem.20201745.Peer-Reviewed Original ResearchConceptsLiver sinusoidal endothelial cellsPortal hypertensionEndothelial cell homeostasisHepatic endothelial cellsEndothelial cellsLiver diseaseUnexplained portal hypertensionGlobal health problemSinusoidal endothelial cellsCell homeostasisSingle-cell RNA-sequencing analysisHypertensionMouse modelHealth problemsMice resultsGimap5RNA sequence analysisMajor contributorCritical regulatorDiseaseCellsDamaging mutationsHomeostasisDecompensationMorbidity
2014
Shared developmental programme strongly constrains beak shape diversity in songbirds
Fritz JA, Brancale J, Tokita M, Burns KJ, Hawkins MB, Abzhanov A, Brenner MP. Shared developmental programme strongly constrains beak shape diversity in songbirds. Nature Communications 2014, 5: 3700. PMID: 24739280, DOI: 10.1038/ncomms4700.Peer-Reviewed Original ResearchConceptsDevelopmental programBeak shapeGrowth zoneNatural selectionBeak developmentStriking diversityDevelopmental mechanismsShape diversityBird's beak shapeCell proliferationZebra finchesDiversityDiverse groupModel systemSongbirdsComparative morphometric analysisSuch variationPhylogenyObserved variationRelative importanceMorphometric analysisFinchesBeakProliferationShape variability