IRX5 promotes DNA damage repair and activation of hair follicle stem cells
Chen J, Wiedemann J, Nguyen L, Lin Z, Tahir M, Hui C, Plikus M, Andersen B. IRX5 promotes DNA damage repair and activation of hair follicle stem cells. Stem Cell Reports 2023, 18: 1227-1243. PMID: 37084727, PMCID: PMC10202659, DOI: 10.1016/j.stemcr.2023.03.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNA DamageGene Expression RegulationHair FollicleHomeodomain ProteinsMiceSignal TransductionStem CellsTranscription FactorsConceptsDNA damage repairDamage repairStem cellsDNA damageDNA damage repair genesCell cycle progressionHair follicle stem cellsEpidermal stem cellsFollicle stem cellsIrx genesChromatin regionsHFSC proliferationHFSC activationInterfollicular epidermal stem cellsDownstream targetsCycle progressionIRX5Molecular mechanismsRepair genesFGF18 expressionAnagen onsetBRCA1 expressionQuiescent phenotypeGenesPromoter