A human autoimmune organoid model reveals IL-7 function in coeliac disease
Santos A, van Unen V, Lin Z, Chirieleison S, Ha N, Batish A, Chan J, Cedano J, Zhang E, Mu Q, Guh-Siesel A, Tomaske M, Colburg D, Varma S, Choi S, Christophersen A, Baghdasaryan A, Yost K, Karlsson K, Ha A, Li J, Dai H, Sellers Z, Chang H, Dunn J, Zhang B, Mellins E, Sollid L, Fernandez-Becker N, Davis M, Kuo C. A human autoimmune organoid model reveals IL-7 function in coeliac disease. Nature 2024, 632: 401-410. PMID: 39048815, DOI: 10.1038/s41586-024-07716-2.Peer-Reviewed Original ResearchMeSH KeywordsAutoantibodiesAutoimmunityBiopsyB-LymphocytesCeliac DiseaseDuodenumEpitopesGlutensGTP-Binding ProteinsHLA-DQ AntigensHumansInterleukin-7Intestinal MucosaKiller Cells, NaturalModels, BiologicalMyeloid CellsOrganoidsProtein Glutamine gamma Glutamyltransferase 2Receptors, Antigen, B-CellReceptors, Antigen, T-CellT-LymphocytesConceptsInterleukin-7Major histocompatibility complexT cellsEpithelial destructionNatural killer (NK) cellsCoeliac diseaseTissue-resident immune cellsB cell receptor repertoiresOrganoid modelsModels of autoimmunityAir-liquid interfaceGluten-free dietActive CeDRemission diseaseIn vitro modelImmune microenvironmentEndoscopic biopsyMyeloid subsetsAutoantibody productionMyeloid cellsPatient biopsiesHLA-DQ8Immune cellsAnti-transglutaminasePlasma cells