2013
The simplest explanation: passive DNA demethylation in PGCs
Smith ZD, Meissner A. The simplest explanation: passive DNA demethylation in PGCs. The EMBO Journal 2013, 32: 318-321. PMID: 23299938, PMCID: PMC3567498, DOI: 10.1038/emboj.2012.349.Peer-Reviewed Original Research
2012
DNA Methylation Dynamics during In Vivo Differentiation of Blood and Skin Stem Cells
Bock C, Beerman I, Lien WH, Smith ZD, Gu H, Boyle P, Gnirke A, Fuchs E, Rossi DJ, Meissner A. DNA Methylation Dynamics during In Vivo Differentiation of Blood and Skin Stem Cells. Molecular Cell 2012, 47: 633-647. PMID: 22841485, PMCID: PMC3428428, DOI: 10.1016/j.molcel.2012.06.019.Peer-Reviewed Original ResearchConceptsDNA methylationHigh-resolution DNA methylation mapsVivo differentiationLineage-associated transcription factorsAdult stem cell differentiationDNA methylation mapsDNA methylation dynamicsGenome-scale dataCellular differentiation hierarchiesDNA methylation changesStem cellsStem cell differentiationAdult stem cellsTranscription factor activationSkin stem cellsMethylation mapsGenomic distributionMethylation dynamicsDifferentiation hierarchyEpigenetic regulationBlood lineagesTranscription factorsTissue homeostasisMethylation changesGene expressionA unique regulatory phase of DNA methylation in the early mammalian embryo
Smith ZD, Chan MM, Mikkelsen TS, Gu H, Gnirke A, Regev A, Meissner A. A unique regulatory phase of DNA methylation in the early mammalian embryo. Nature 2012, 484: 339-344. PMID: 22456710, PMCID: PMC3331945, DOI: 10.1038/nature10960.Peer-Reviewed Original ResearchConceptsDNA methylationGenome-scale DNA methylation mapsLong terminal repeat (LTR) retroelementsDNA methylation mapsBase-resolution mapsEarly mammalian embryoCpG island promotersBlastocyst stageMammalian embryogenesisMethylation mapsPaternal genomeMammalian embryosEpigenetic modificationsEarly embryosSomatic cellsGlobal hypomethylationSomatic patternMouse gametesElement 1MethylationEmbryosMethylation valuesRegulatory phaseGametesZygotesGel-free multiplexed reduced representation bisulfite sequencing for large-scale DNA methylation profiling
Boyle P, Clement K, Gu H, Smith ZD, Ziller M, Fostel JL, Holmes L, Meldrim J, Kelley F, Gnirke A, Meissner A. Gel-free multiplexed reduced representation bisulfite sequencing for large-scale DNA methylation profiling. Genome Biology 2012, 13: r92. PMID: 23034176, PMCID: PMC3491420, DOI: 10.1186/gb-2012-13-10-r92.Peer-Reviewed Original Research