2014
DNA methylation dynamics of the human preimplantation embryo
Smith ZD, Chan MM, Humm KC, Karnik R, Mekhoubad S, Regev A, Eggan K, Meissner A. DNA methylation dynamics of the human preimplantation embryo. Nature 2014, 511: 611-615. PMID: 25079558, PMCID: PMC4178976, DOI: 10.1038/nature13581.Peer-Reviewed Original ResearchConceptsGenome-scale DNA methylationMaternal-specific methylationDNA methylation dynamicsTransposable element activityEmbryonic stem cell derivationStem cell derivationEarly human embryogenesisHuman preimplantation embryosMethylation dynamicsDNA methylationHuman embryogenesisElement activityPreimplantation embryosCell derivationUnique modeMethylationEmbryogenesisMouse modelEmbryosRegulationExpression
2012
DNA Methylation Dynamics during In Vivo Differentiation of Blood and Skin Stem Cells
Bock C, Beerman I, Lien WH, Smith ZD, Gu H, Boyle P, Gnirke A, Fuchs E, Rossi DJ, Meissner A. DNA Methylation Dynamics during In Vivo Differentiation of Blood and Skin Stem Cells. Molecular Cell 2012, 47: 633-647. PMID: 22841485, PMCID: PMC3428428, DOI: 10.1016/j.molcel.2012.06.019.Peer-Reviewed Original ResearchConceptsDNA methylationHigh-resolution DNA methylation mapsVivo differentiationLineage-associated transcription factorsAdult stem cell differentiationDNA methylation mapsDNA methylation dynamicsGenome-scale dataCellular differentiation hierarchiesDNA methylation changesStem cellsStem cell differentiationAdult stem cellsTranscription factor activationSkin stem cellsMethylation mapsGenomic distributionMethylation dynamicsDifferentiation hierarchyEpigenetic regulationBlood lineagesTranscription factorsTissue homeostasisMethylation changesGene expression