2024
Reconstructing axial progenitor field dynamics in mouse stem cell-derived embryoids
Bolondi A, Law B, Kretzmer H, Gassaloglu S, Buschow R, Riemenschneider C, Yang D, Walther M, Veenvliet J, Meissner A, Smith Z, Chan M. Reconstructing axial progenitor field dynamics in mouse stem cell-derived embryoids. Developmental Cell 2024, 59: 1489-1505.e14. PMID: 38579718, PMCID: PMC11187653, DOI: 10.1016/j.devcel.2024.03.024.Peer-Reviewed Original ResearchNeuro-mesodermal progenitorsFate outcomesStem cell-based modelsEmbryonic trunkEnvironmental cuesMorphological phenotypesDownstream lineagesMolecular recordCell-based modelsCell typesTranscriptional signatureComplex tissuesAxial progenitorsLineagesDevelopmental timeNeural lineagesTransient progenitor populationProgenitor populationsDevelopmental windowPhylogeny
2015
Epigenetic predisposition to reprogramming fates in somatic cells
Pour M, Pilzer I, Rosner R, Smith ZD, Meissner A, Nachman I. Epigenetic predisposition to reprogramming fates in somatic cells. EMBO Reports 2015, 16: 370-378. PMID: 25600117, PMCID: PMC4364876, DOI: 10.15252/embr.201439264.Peer-Reviewed Original ResearchConceptsSomatic cellsFactor inductionLive-cell imagingPluripotent stem cellsEpigenetic stateCell identitySuccessful reprogrammingEpigenetic heterogeneityDaughter cellsSister cellsCell lineagesCellular responsesLineagesEZH2 inhibitorsLow-efficiency processColony formationStem cellsEpigenetic predispositionReprogramPopulation levelCellsNovel statistical approachSomatic populationInductionFate