Analysis of immunological mechanisms exerted by HBsAg-HBIG therapeutic vaccine combined with Adefovir in chronic hepatitis B patients
Zhou C, Li C, Gong G, Wang S, Zhang J, Xu D, Guo L, Ren H, Xu M, Xie Q, Pan C, Xu J, Hu Z, Geng S, Zhou X, Wang X, Zhou X, Mi H, Zhao G, Yu W, Wen Y, Huang L, Wang X, Wang B. Analysis of immunological mechanisms exerted by HBsAg-HBIG therapeutic vaccine combined with Adefovir in chronic hepatitis B patients. Human Vaccines & Immunotherapeutics 2017, 13: 1989-1996. PMID: 28665747, PMCID: PMC5612521, DOI: 10.1080/21645515.2017.1335840.Peer-Reviewed Original ResearchMeSH KeywordsAdenineAdjuvants, ImmunologicAdultAntigen-Antibody ComplexCombined Modality TherapyFemaleHepatitis B Surface AntigensHepatitis B VaccinesHepatitis B, ChronicHumansInterleukin-10Interleukin-17Interleukin-2MaleOrganophosphonatesTh1 CellsTh2 CellsTransforming Growth Factor betaTumor Necrosis Factor-alphaYoung AdultConceptsChronic hepatitis B patientsHepatitis B patientsT cellsImmunized groupsB patientsImmunological mechanismsTherapeutic vaccinesHost-specific immune responseIL-2 levelsSero-conversion rateSpecific immune responseEarly inflammatory responseCHB patientsTc17 cellsTreg cellsCytokine profileIL-17AIL-10Saline groupCell CD4More injectionsAdjuvant controlsClinical trialsInflammatory responseNormal saline