Carbamylated erythropoietin promotes neurite outgrowth and neuronal spine formation in association with CBP/p300
Choi M, Ko SY, Lee IY, Wang SE, Lee SH, Oh DH, Kim YS, Son H. Carbamylated erythropoietin promotes neurite outgrowth and neuronal spine formation in association with CBP/p300. Biochemical And Biophysical Research Communications 2014, 446: 79-84. PMID: 24607903, DOI: 10.1016/j.bbrc.2014.02.066.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCells, CulturedDisks Large Homolog 4 ProteinE1A-Associated p300 ProteinEpigenesis, GeneticErythropoietinIntracellular Signaling Peptides and ProteinsMAP Kinase Signaling SystemMembrane ProteinsNerve Tissue ProteinsNeuritesNeurogenesisNeuronsPhosphorylationProto-Oncogene Proteins c-aktRatsSTAT3 Transcription FactorTranscriptional ActivationTumor Suppressor Protein p53Up-RegulationConceptsNeuronal differentiationNeuronal spine formationCBP/p300E1A-binding proteinSpine formationTreatment of cellsEpigenetic modificationsTranscription factorsSubsequent transactivationTarget genesTransactivation activityGene expressionMolecular mechanismsImportant medical implicationsLength of neuritesP53 acetylationNeurite outgrowthGrowth-associated protein 43TransactivationAcetylationMedical implicationsDifferentiationProtein 43Spine densityNeuropsychiatric disorders