2015
Ketamine produces antidepressant-like effects through phosphorylation-dependent nuclear export of histone deacetylase 5 (HDAC5) in rats
Choi M, Lee SH, Wang SE, Ko SY, Song M, Choi JS, Kim YS, Duman RS, Son H. Ketamine produces antidepressant-like effects through phosphorylation-dependent nuclear export of histone deacetylase 5 (HDAC5) in rats. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 15755-15760. PMID: 26647181, PMCID: PMC4697416, DOI: 10.1073/pnas.1513913112.Peer-Reviewed Original ResearchConceptsHistone deacetylase 5Myocyte enhancer factor 2MEF2 target genesNuclear exportTarget genesTranscriptional activityPhosphorylation-dependent nuclear exportPhosphorylation-defective mutantProtein kinase DHistone deacetylase 5 (HDAC5) phosphorylationMEF2 transcriptional activityAntidepressant-like effectsCalcium/calmodulin kinase IICalmodulin kinase IIKinase DKinase IIMolecular mechanismsNovel roleRapid antidepressant-like effectsDependent pathwayAction of ketamineFactor 2Rat hippocampal neuronsGenesHippocampal knockdown
2014
Carbamylated erythropoietin promotes neurite outgrowth and neuronal spine formation in association with CBP/p300
Choi M, Ko SY, Lee IY, Wang SE, Lee SH, Oh DH, Kim YS, Son H. Carbamylated erythropoietin promotes neurite outgrowth and neuronal spine formation in association with CBP/p300. Biochemical And Biophysical Research Communications 2014, 446: 79-84. PMID: 24607903, DOI: 10.1016/j.bbrc.2014.02.066.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCells, CulturedDisks Large Homolog 4 ProteinE1A-Associated p300 ProteinEpigenesis, GeneticErythropoietinIntracellular Signaling Peptides and ProteinsMAP Kinase Signaling SystemMembrane ProteinsNerve Tissue ProteinsNeuritesNeurogenesisNeuronsPhosphorylationProto-Oncogene Proteins c-aktRatsSTAT3 Transcription FactorTranscriptional ActivationTumor Suppressor Protein p53Up-RegulationConceptsNeuronal differentiationNeuronal spine formationCBP/p300E1A-binding proteinSpine formationTreatment of cellsEpigenetic modificationsTranscription factorsSubsequent transactivationTarget genesTransactivation activityGene expressionMolecular mechanismsImportant medical implicationsLength of neuritesP53 acetylationNeurite outgrowthGrowth-associated protein 43TransactivationAcetylationMedical implicationsDifferentiationProtein 43Spine densityNeuropsychiatric disorders