2018
IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis
Jo S, Wang SE, Lee YL, Kang S, Lee B, Han J, Sung IH, Park YS, Bae SC, Kim TH. IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis. Arthritis Research & Therapy 2018, 20: 115. PMID: 29880011, PMCID: PMC5992730, DOI: 10.1186/s13075-018-1582-3.Peer-Reviewed Original ResearchConceptsIL-17AJAK2/STAT3Rheumatoid arthritisHealthy controlsExogenous IL-17AIL-12/23 p40Abnormal bone formationNew rational therapiesStimulus-induced increaseALP activityBone tissue samplesPrimary BdCsControl patientsExtensive inflammationAS pathogenesisBony ankylosisP40 levelsSpinal diseaseFacet jointsRational therapySynovial fluidPatientsPrimary bone-derived cellsBone-derived cellsJAK2 inhibitors
2014
Carbamylated erythropoietin promotes neurite outgrowth and neuronal spine formation in association with CBP/p300
Choi M, Ko SY, Lee IY, Wang SE, Lee SH, Oh DH, Kim YS, Son H. Carbamylated erythropoietin promotes neurite outgrowth and neuronal spine formation in association with CBP/p300. Biochemical And Biophysical Research Communications 2014, 446: 79-84. PMID: 24607903, DOI: 10.1016/j.bbrc.2014.02.066.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCells, CulturedDisks Large Homolog 4 ProteinE1A-Associated p300 ProteinEpigenesis, GeneticErythropoietinIntracellular Signaling Peptides and ProteinsMAP Kinase Signaling SystemMembrane ProteinsNerve Tissue ProteinsNeuritesNeurogenesisNeuronsPhosphorylationProto-Oncogene Proteins c-aktRatsSTAT3 Transcription FactorTranscriptional ActivationTumor Suppressor Protein p53Up-RegulationConceptsNeuronal differentiationNeuronal spine formationCBP/p300E1A-binding proteinSpine formationTreatment of cellsEpigenetic modificationsTranscription factorsSubsequent transactivationTarget genesTransactivation activityGene expressionMolecular mechanismsImportant medical implicationsLength of neuritesP53 acetylationNeurite outgrowthGrowth-associated protein 43TransactivationAcetylationMedical implicationsDifferentiationProtein 43Spine densityNeuropsychiatric disorders