Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice
Wang SE, Ko SY, Kim YS, Jo S, Lee SH, Jung SJ, Son H. Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice. Experimental & Molecular Medicine 2018, 50: e455-e455. PMID: 29520110, PMCID: PMC5898893, DOI: 10.1038/emm.2017.289.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCapsaicinCells, CulturedChromatin ImmunoprecipitationHippocampusHistone Deacetylase 2ImmunohistochemistryMaleMiceMice, Inbred C57BLNeurogenesisNeuronsTRPV Cation ChannelsConceptsTransient receptor potential vanilloid 1Histone deacetylase 2Synapsin IAgonist of TRPV1Synaptic plasticityRole of HDAC2GluR2 promoterCapsaicin treatmentVanilloid 1Neuronal maturationMouse hippocampusTRPV1 activityHippocampal knockdownChromatin remodelingTranscriptional regulationSynaptic moleculesCapsaicinMolecular linkGene expressionMicePresent studyDetrimental effectsRegulationSynaptophysinHippocampus