2017
Oleanolic Acid Promotes Neuronal Differentiation and Histone Deacetylase 5 Phosphorylation in Rat Hippocampal Neurons
Jo HR, Wang SE, Kim YS, Lee CH, Son H. Oleanolic Acid Promotes Neuronal Differentiation and Histone Deacetylase 5 Phosphorylation in Rat Hippocampal Neurons. Molecules And Cells 2017, 40: 485-494. PMID: 28681592, PMCID: PMC5547218, DOI: 10.14348/molcells.2017.0034.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAnimalsCell DifferentiationCell NucleusDendritic SpinesGene Expression RegulationHippocampusHistone DeacetylasesMEF2 Transcription FactorsNeural Stem CellsNeuritesNeuronsOleanolic AcidPhosphorylationProtein Kinase CRats, Sprague-DawleySubcellular FractionsSynapsesConceptsRat hippocampal neural progenitor cellsEffects of OAHippocampal neural progenitor cellsNeuronal differentiationOA derivativesOleanolic acidHDAC5 phosphorylationHistone deacetylase 5 (HDAC5) phosphorylationRat hippocampal neuronsNeural progenitor cellsPromotes Neuronal DifferentiationHistone deacetylase 5Neurotrophic effectsHippocampal neuronsNeurological drugsProgenitor cellsNeural differentiationNeuronsPresent studyTarget genesExpressionFurther researchGene expressionPhosphorylationDifferentiation
2015
Ketamine produces antidepressant-like effects through phosphorylation-dependent nuclear export of histone deacetylase 5 (HDAC5) in rats
Choi M, Lee SH, Wang SE, Ko SY, Song M, Choi JS, Kim YS, Duman RS, Son H. Ketamine produces antidepressant-like effects through phosphorylation-dependent nuclear export of histone deacetylase 5 (HDAC5) in rats. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 15755-15760. PMID: 26647181, PMCID: PMC4697416, DOI: 10.1073/pnas.1513913112.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAnimalsAntidepressive AgentsCell NucleusCells, CulturedHippocampusHistone DeacetylasesKetamineMEF2 Transcription FactorsPhosphorylationRatsRats, Sprague-DawleyConceptsHistone deacetylase 5Myocyte enhancer factor 2MEF2 target genesNuclear exportTarget genesTranscriptional activityPhosphorylation-dependent nuclear exportPhosphorylation-defective mutantProtein kinase DHistone deacetylase 5 (HDAC5) phosphorylationMEF2 transcriptional activityAntidepressant-like effectsCalcium/calmodulin kinase IICalmodulin kinase IIKinase DKinase IIMolecular mechanismsNovel roleRapid antidepressant-like effectsDependent pathwayAction of ketamineFactor 2Rat hippocampal neuronsGenesHippocampal knockdown