2017
Oleanolic Acid Promotes Neuronal Differentiation and Histone Deacetylase 5 Phosphorylation in Rat Hippocampal Neurons
Jo HR, Wang SE, Kim YS, Lee CH, Son H. Oleanolic Acid Promotes Neuronal Differentiation and Histone Deacetylase 5 Phosphorylation in Rat Hippocampal Neurons. Molecules And Cells 2017, 40: 485-494. PMID: 28681592, PMCID: PMC5547218, DOI: 10.14348/molcells.2017.0034.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAnimalsCell DifferentiationCell NucleusDendritic SpinesGene Expression RegulationHippocampusHistone DeacetylasesMEF2 Transcription FactorsNeural Stem CellsNeuritesNeuronsOleanolic AcidPhosphorylationProtein Kinase CRats, Sprague-DawleySubcellular FractionsSynapsesConceptsRat hippocampal neural progenitor cellsEffects of OAHippocampal neural progenitor cellsNeuronal differentiationOA derivativesOleanolic acidHDAC5 phosphorylationHistone deacetylase 5 (HDAC5) phosphorylationRat hippocampal neuronsNeural progenitor cellsPromotes Neuronal DifferentiationHistone deacetylase 5Neurotrophic effectsHippocampal neuronsNeurological drugsProgenitor cellsNeural differentiationNeuronsPresent studyTarget genesExpressionFurther researchGene expressionPhosphorylationDifferentiation
2014
Overexpression of Human GATA-1 and GATA-2 Interferes with Spine Formation and Produces Depressive Behavior in Rats
Choi M, Wang SE, Ko SY, Kang HJ, Chae SY, Lee SH, Kim YS, Duman RS, Son H. Overexpression of Human GATA-1 and GATA-2 Interferes with Spine Formation and Produces Depressive Behavior in Rats. PLOS ONE 2014, 9: e109253. PMID: 25340772, PMCID: PMC4207676, DOI: 10.1371/journal.pone.0109253.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalCells, CulturedDendritic SpinesDependovirusDepressionGATA1 Transcription FactorGATA2 Transcription FactorGene Expression RegulationGreen Fluorescent ProteinsHippocampusHumansMaleRats, Sprague-DawleyRats, TransgenicRNA, Small InterferingSynapsesTranscription, GeneticConceptsSynapse-related genesSpine numberDentate gyrusDepressive behaviorDorsal hippocampusHippocampal neuronsSpine formationViral expressionDepressive-like deficitsSpine synapse densitySynapse-related gene expressionEffects of adenoRat hippocampal neuronsViral-mediated expressionModel of depressionSwim testSynapse densityDendritic outgrowthAdult brainHippocampusNeuronal differentiationDendrite branchingShRNA knockdownGATA-2Helplessness model