Overexpression of Human GATA-1 and GATA-2 Interferes with Spine Formation and Produces Depressive Behavior in Rats
Choi M, Wang SE, Ko SY, Kang HJ, Chae SY, Lee SH, Kim YS, Duman RS, Son H. Overexpression of Human GATA-1 and GATA-2 Interferes with Spine Formation and Produces Depressive Behavior in Rats. PLOS ONE 2014, 9: e109253. PMID: 25340772, PMCID: PMC4207676, DOI: 10.1371/journal.pone.0109253.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalCells, CulturedDendritic SpinesDependovirusDepressionGATA1 Transcription FactorGATA2 Transcription FactorGene Expression RegulationGreen Fluorescent ProteinsHippocampusHumansMaleRats, Sprague-DawleyRats, TransgenicRNA, Small InterferingSynapsesTranscription, GeneticConceptsSynapse-related genesSpine numberDentate gyrusDepressive behaviorDorsal hippocampusHippocampal neuronsSpine formationViral expressionDepressive-like deficitsSpine synapse densitySynapse-related gene expressionEffects of adenoRat hippocampal neuronsViral-mediated expressionModel of depressionSwim testSynapse densityDendritic outgrowthAdult brainHippocampusNeuronal differentiationDendrite branchingShRNA knockdownGATA-2Helplessness model