IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis
Jo S, Wang SE, Lee YL, Kang S, Lee B, Han J, Sung IH, Park YS, Bae SC, Kim TH. IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis. Arthritis Research & Therapy 2018, 20: 115. PMID: 29880011, PMCID: PMC5992730, DOI: 10.1186/s13075-018-1582-3.Peer-Reviewed Original ResearchConceptsIL-17AJAK2/STAT3Rheumatoid arthritisHealthy controlsExogenous IL-17AIL-12/23 p40Abnormal bone formationNew rational therapiesStimulus-induced increaseALP activityBone tissue samplesPrimary BdCsControl patientsExtensive inflammationAS pathogenesisBony ankylosisP40 levelsSpinal diseaseFacet jointsRational therapySynovial fluidPatientsPrimary bone-derived cellsBone-derived cellsJAK2 inhibitors